Intradermal HBV Vaccine Efficient for Intramuscular Nonresponders

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Intradermal HBV Vaccine Efficient for Intramuscular Nonresponders
Intradermal HBV Vaccine Efficient for Intramuscular Nonresponders

THURSDAY, June 25, 2015 (HealthDay News) -- For intramuscular hepatitis B virus (HBV) vaccine nonresponders, intradermal vaccine administration seems efficacious and safe, according to a study published online June 23 in the Journal of Gastroenterology and Hepatology.

Or Kalchiem-Dekel, M.D., from the Soroka University Medical Center in Israel, and colleagues designed a prospective case series to examine efficacy, safety, and durability of intradermal vaccine administration in those who have not responded well to intramuscular HBV vaccine. The medical records of 4,007 heath care personnel who worked in the hospital between 1996 and 2006 were examined, and the researchers identified nonresponders who had an unsatisfactory level of hepatitis B surface antibody (HBsAb) after two courses of a three-dose intramuscular HBV vaccine. They were vaccinated with three doses of 5 µg intradermal recombinant HBs antigen (HBsAg)-based vaccine. Data were included for 27 subjects, of whom 21 completed the study.

The researchers found that 70.3 percent of subjects had a satisfactory HBsAb level at four weeks after the last administered dose. At 24 weeks, sustained immune response was seen in 62.9 percent of subjects based on intention-to-treat analysis and 80.9 percent based on per-protocol analysis. No adverse events in response to vaccine administration were reported.

"Intradermal administration of HBV vaccine offers an efficient, safe, and durable option for intramuscular vaccine nonresponders, and represents a means to optimize utilization of the widespread HBsAg-based vaccine formulation," the authors write.

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