Intermittent Steroids Reduce Some Asthma Exacerbations

Share this content:
Intermittent Steroids Reduce Some Asthma Exacerbations
Intermittent Steroids Reduce Some Asthma Exacerbations

FRIDAY, May 27, 2016 (HealthDay News) -- There is strong evidence to support intermittent inhaled corticosteroids (ICS) for prevention of wheeze exacerbations in preschool children with intermittent asthma or viral-triggered wheezing, according to a review published online May 26 in Pediatrics.

Sunitha Kaiser, M.D., of the University of California, San Francisco, and colleagues analyzed 22 studies involving 4,550 children age 6 and younger. All had at least two episodes of asthma or wheezing in the previous year.

In 15 of the studies, children with persistent asthma or wheezing had a 30 percent reduction in the risk of exacerbation with daily medium-dose ICS use. Five other studies focused on more sporadic use of the inhalers by children whose wheezing was not persistent, and was typically only spurred by a cold. Those studies found a 35 percent reduction in exacerbations with high-dose intermittent ICS use compared to a placebo. Two more studies compared the effects of daily ICS and more sporadic ICS use in children with wheezing induced by common colds. Those studies found no difference in the number of exacerbations. There were no studies that compared daily-versus-intermittent use of ICS for children with chronic, daily asthma or wheeze.

"There is strong evidence to support daily ICS for preventing exacerbations in preschool children with recurrent wheeze, specifically in children with persistent asthma," the authors conclude. "For preschool children with intermittent asthma or viral-triggered wheezing, there is strong evidence to support intermittent ICS for preventing exacerbations."

Two authors disclosed financial ties to the pharmaceutical industry.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Attempted Suicide Rates, Risk Groups Mostly Unchanged

Attempted Suicide Rates, Risk Groups Mostly Unchanged

Men more often resort to violent means, while women turn to poisoning, drowning

New Visual Symptoms Not Uncommon After LASIK Surgery

New Visual Symptoms Not Uncommon After LASIK Surgery

But most patients report satisfaction with the procedure

Many With Postconcussion Syndrome Don't Recover

Many With Postconcussion Syndrome Don't Recover

Only 27 percent of population recovered; 67 percent of those who recovered did so in first year

is free, fast, and customized just for you!

Already a member?

Sign In Now »