Inhibition of mTOR Restores Corticosteroid Sensitivity in COPD

Share this content:
Inhibition of mTOR Restores Corticosteroid Sensitivity in COPD
Inhibition of mTOR Restores Corticosteroid Sensitivity in COPD

FRIDAY, Jan. 22, 2016 (HealthDay News) -- Inhibition of mammalian target of rapamycin (mTOR) by rapamycin restores corticosteroid sensitivity in patients with chronic obstructive pulmonary disease (COPD), according to a study published in the Jan. 15 issue of the American Journal of Respiratory and Critical Care Medicine.

Akihisa Mitani, M.D., Ph.D., from Imperial College London, and colleagues examined the role of mTOR in corticosteroid sensitivity in COPD. Corticosteroid sensitivity was assessed in peripheral blood mononuclear cells obtained from patients with COPD, smokers, and nonsmoking controls, as well as in human monocytic U937 cells exposed to cigarette smoke extract (CSE), in the presence and absence of the mTOR inhibitor rapamycin.

The researchers observed increased mTOR activity in peripheral blood mononuclear cells from patients with COPD, which was inhibited by rapamycin treatment. Rapamycin treatment also restored corticosteroid sensitivity. CSE stimulated mTOR activity and c-Jun expression in U937 cells; rapamycin pretreatment inhibited both and reversed corticosteroid insensitivity induced by CSE.

"mTOR inhibition by rapamycin restores corticosteroid sensitivity via inhibition of c-Jun expression, and thus mTOR is a potential novel therapeutic target for COPD," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Surveillance Frequency Doesn't Cut Mortality in Colorectal Cancer

Surveillance Frequency Doesn't Cut Mortality in Colorectal Cancer

And, intensity of imaging surveillance not linked to time to detection of colorectal cancer recurrence

Procalcitonin Assay Doesn't Cut Antibiotic Use in Lower RTI

Procalcitonin Assay Doesn't Cut Antibiotic Use in Lower ...

Provision of assay doesn't result in less antibiotic use for suspected lower respiratory tract infection

Preventing Child Maltreatment Not Yet Feasible in Primary Care

Preventing Child Maltreatment Not Yet Feasible in Primary ...

USPSTF says evidence inadequate for primary care interventions to prevent child maltreatment

is free, fast, and customized just for you!

Already a member?

Sign In Now »