Inhaled Corticosteroids Not Linked to Pneumonia in Children

Share this content:
Inhaled Corticosteroids Not Linked to Pneumonia in Children
Inhaled Corticosteroids Not Linked to Pneumonia in Children

MONDAY, Feb. 27, 2017 (HealthDay News) -- Inhaled corticosteroids (ICS) do not appear to be associated with the risk of pneumonia in children with asthma, according to a review published online Feb. 24 in Pediatrics.

Cristine Cazeiro, B.S.N., from the Federal University of Rio Grande in Brazil, and colleagues examined the correlation between ICS use and risk of pneumonia and other respiratory infections among children with asthma. Thirty-nine randomized trials that compared ICS with placebo for at least four weeks were selected, of which 31 trials with 11,615 patients contributed data to meta-analyses.

The researchers found that the incidence of pneumonia was 0.58 and 1.51 percent, respectively, in the ICS and placebo groups. Based on a meta-analysis of nine trials that revealed at least one pneumonia event, the risk of pneumonia was reduced in patients taking ICS (risk ratio, 0.65; 95 percent confidence interval [CI], 0.44 to 0.94). The meta-analysis including all 31 trials showed no significant between-group difference in the risk of pneumonia (risk difference, −0.1 percent; 95 percent CI, −0.3 to 0.2 percent) using risk difference as effect measure. ICS was not significantly associated with the risk of pharyngitis, otitis media, or sinusitis (risk ratios, 1.01 [95 percent CI, 0.87 to 1.18], 1.07 [95 percent CI, 0.83 to 1.37], and 0.89 [95 percent CI, 0.76 to 1.05]).

"Regular use of ICS may not increase the risk of pneumonia or other respiratory infections in children with asthma," the authors write.

One author disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Osimertinib Tops Standard EGFR-TKI for EGFR NSCLC

Osimertinib Tops Standard EGFR-TKI for <i>EGFR</i>&#43; NSCLC

Significantly longer median progression-free survival for osimertinib in previously untreated NSCLC

Distinct Features for Drug Use-Related Endophthalmitis

Distinct Features for Drug Use-Related Endophthalmitis

Injection drug users have fewer comorbidities and more improvement in visual acuity after intervention

Dating Violence Victimization, Nonmedical Rx Med Use Linked

Dating Violence Victimization, Nonmedical Rx Med Use Linked

Nonmedical use of prescription drugs linked to dating violence for male, female high school students

is free, fast, and customized just for you!

Already a member?

Sign In Now »