Infusion of Umbilical Cord Stem Cells Safe, Effective in HFrEF

Share this content:
Infusion of Umbilical Cord Stem Cells Safe, Effective in HFrEF
Infusion of Umbilical Cord Stem Cells Safe, Effective in HFrEF

WEDNESDAY, Sept. 27, 2017 (HealthDay News) -- Intravenous infusion of umbilical cord-derived mesenchymal stem cells (UC-MSCs) is safe and efficacious for patients with heart failure and reduced ejection fraction (HFrEF), according to a study published online Sept. 26 in Circulation Research.

Jorge Bartolucci, M.D., from the Universidad de los Andes in Chile, and colleagues randomized HFrEF patients under optimal medical treatment to intravenous infusion of allogeneic UC-MSCs or placebo (15 in each group) to assess the safety and efficacy of the infusion of UC-MSCs.

The researchers found that, compared with bone marrow-derived mesenchymal stem cells, UC-MSCs in vitro displayed a 55-fold increase in the expression of hepatocyte growth factor. No adverse events related to cell infusion were seen in UC-MSC treated patients; at 0, 15, and 90 days, none of the seven patients tested presented alloantibodies to the UC-MSCs. The UC-MSC group exhibited significant improvements in left ventricular ejection fraction at three, six, and 12 months of follow-up. From baseline to month 12 there was a significant difference between the groups in echocardiographic left ventricular ejection fraction. Furthermore, at all follow-up time points, there were improvements in New York Heart Association functional class and in Minnesota Living with Heart Failure Questionnaire in UC-MSC-treated patients.

"Improvements in left ventricular function, functional status, and quality of life were observed in patients treated with UC-MSCs," the authors write.

Several authors disclosed financial ties to the biotechnology industry.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

FDA Approves First Drug for Rare Form of Rickets

FDA Approves First Drug for Rare Form of ...

Crysvita approved for adults and children ages 1 year and older with x-linked hypophosphatemia

High FGF-23 Linked to Recurrent Cardiac Events After ACS

High FGF-23 Linked to Recurrent Cardiac Events After ...

FGF-23 in top quartile independently linked to greater risk of CV death, heart failure hospitalization

Medical Cannabis Not Recommended for Sleep Apnea

Medical Cannabis Not Recommended for Sleep Apnea

American Academy of Sleep Medicine says evidence insufficient to recommend cannabis for apnea

is free, fast, and customized just for you!

Already a member?

Sign In Now »