Industry-Led Oncology Trials May Inflate Cost-Effectiveness

Share this content:
Industry-Led Oncology Trials May Inflate Cost-Effectiveness
Industry-Led Oncology Trials May Inflate Cost-Effectiveness

FRIDAY, Dec. 11, 2015 (HealthDay News) -- Pharmaceutical industry-sponsored studies are more likely to report favorable estimates in cost-effectiveness analysis (CEA) of drugs used in breast cancer treatment, according to a research letter published online Dec. 10 in JAMA Oncology.

Jordan D. Lane, M.D., from the Walter Reed National Military Medical Center in Bethesda, Md., and colleagues examined CEAs for breast cancer from the Tufts Cost-Effectiveness Analysis Registry. Independent associations between industry sponsorship and study results were estimated, after adjustment for drug class, cancer stage targeted, and study quality score.

The researchers found that 65 of the 105 CEA studies were industry funded. Industry-sponsored studies had nonsignificantly higher study quality ratings (mean rating, 4.8 versus 4.4 for studies with other sponsorship; P = 0.09). Industry-sponsored studies were significantly more likely to report favorable cost-effectiveness results compared with other sponsored studies (75.4 versus 40.0 percent at $50,000/quality-adjusted life-year [QALY]; P = 0.004). Industry-sponsored studies were more likely to report favorable findings among the subset of CEAs with high quality ratings (75.5 versus 45.5 percent; P = 0.04 at the $50,000/QALY threshold).

"Our analysis of breast cancer CEAs suggests that pharmaceutical industry-sponsored studies continue to be more likely to report favorable estimates than studies with other sponsorship," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »