Incretin Tied to Better Outcomes in NOCS-Diabetes

This article originally appeared here.
Share this content:
Incretin Tied to Better Outcomes in NOCS-Diabetes
Incretin Tied to Better Outcomes in NOCS-Diabetes

FRIDAY, Oct. 27, 2017 (HealthDay News) -- Incretin treatment appears to improve non-ST-elevation myocardial infarction (NSTEMI) outcomes in patients with type 2 diabetes and non-obstructive coronary artery stenosis (NOCS), according to a study published online Sept. 26 in Diabetes, Obesity and Metabolism.

Raffaele Marfella, M.D., Ph.D., from Università degli Studi della Campania in Italy, and colleagues compared the 12-month prognosis of individuals with NOCS-diabetes (20 to 49 percent luminal stenosis) with first NSTEMI with that of individuals without diabetes. They also investigated the prognosis of NSTEMI-NOCS diabetes patients previously treated with incretin-based therapy with a matched cohort of NSTEMI-NOCS patients never treated with incretin. Patients with diabetes were characterized as current incretin users (six months, GLP-1 agonists or DPP-4 inhibitors) and never incretin users.

The researchers found that all-cause death, cardiac death, readmission for acute coronary syndrome, and heart failure were higher in patients with diabetes than those without diabetes. Among the diabetes patients, current incretin users had a significantly lower rate of all-cause death, cardiac death, and readmission for ACS through the 12-month period.

"In type 2 diabetic patients with NOCS-NSTEMI, we observed higher incidence of one-year mortality, and adverse cardiovascular outcomes, as compared to non-diabetic NOCS-NSTEMI patients. In diabetic patients, never-incretin-users have worse prognosis as compared to current-incretin-users," conclude the authors.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

NAFLD Linked to Smaller Total Cerebral Brain Volume

NAFLD Linked to Smaller Total Cerebral Brain Volume

Significant correlation even after adjustment for all covariates, including age, sex, alcohol consumption

Salivary miRNAs Can ID Duration of Concussion Symptoms

Salivary miRNAs Can ID Duration of Concussion Symptoms

Pediatric patients with prolonged symptoms were accurately identified by levels of five miRNAs

Treatment Trajectories Vary for Children With Depression

Treatment Trajectories Vary for Children With Depression

Most common class got psychotherapy monotherapy, and had lowest incidence of attempted suicide

is free, fast, and customized just for you!

Already a member?

Sign In Now »