Increased Risk of Diabetes With Nonfunctional Adrenal Tumors

Share this content:
Increased Risk of Diabetes With Nonfunctional Adrenal Tumors
Increased Risk of Diabetes With Nonfunctional Adrenal Tumors

THURSDAY, Aug. 4, 2016 (HealthDay News) -- Patients with nonfunctional adrenal tumors (NFATs) have increased risk of diabetes compared to those without adrenal tumors, according to a study published online Aug. 2 in the Annals of Internal Medicine.

In a cohort study, Diana Lopez, M.D., from Brigham and Women's Hospital in Boston, and colleagues examined the hypothesis that presence of NFATs increases the risk for cardiometabolic outcomes. Data were included from 166 participants with benign NFATs and 740 with no adrenal tumor, all with at least three years of follow-up. Medical records were reviewed for the development of incident outcomes (hypertension, composite diabetes [prediabetes or type 2 diabetes], hyperlipidemia, cardiovascular events, and chronic kidney disease) during a mean follow-up of 7.7 years.

The researchers found that the risk of incident composite diabetes was significantly higher for patients with NFATs versus those without adrenal tumors (27.3 versus 11.7 percent; adjusted risk ratio, 1.87). There were no significant correlations between NFATs and other outcomes. There was a correlation for higher "normal" postdexamethasone cortisol levels (≤50 nmol/L) with larger NFAT size and higher prevalence of type 2 diabetes.

"These results should prompt a reassessment of whether the classification of benign adrenal tumors as 'nonfunctional' adequately reflects the continuum of hormone secretion and metabolic risk they may harbor," the authors write.

One author disclosed financial ties to the biopharmaceutical industry.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

MRI Can Be Safe for Patients With Older Pacemakers, ICDs

MRI Can Be Safe for Patients With Older ...

However, strict procedures need to be followed

ASA: Exercise Boosts Cognitive Function After Stroke

ASA: Exercise Boosts Cognitive Function After Stroke

Most effective programs offer exercises aimed at strength, balance, stretching, and aerobic fitness

ASA: Headache Precedes Stroke More Often in Kids Than Adults

ASA: Headache Precedes Stroke More Often in Kids ...

However, ischemic strokes still very rare in children

is free, fast, and customized just for you!

Already a member?

Sign In Now »