Incidence of Statin-Associated T2DM Relatively Low

Share this content:
Incidence of Statin-Associated T2DM Relatively Low
Incidence of Statin-Associated T2DM Relatively Low

WEDNESDAY, Nov. 2, 2016 (HealthDay News) -- For patients without diabetes, the incidence of statin-associated type 2 diabetes mellitus (T2DM) is relatively low, according to research published in the Nov. 1 issue of The American Journal of Cardiology.

Payal Kohli, M.D., from Kaiser Permanente in Denver, and colleagues conducted a retrospective analysis of data from subjects without diabetes in the Treating to New Targets (TNT) and Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trials to identify increased risk of statin-associated T2DM. Participants were subdivided into four groups: normal fasting glucose (NFG) and triglyceride (TG) ≤1.7 mmol/L; NFG and TG >1.7 mmol/L; prediabetes mellitus (PreDM) and TG ≤1.7 mmol/L; and PreDM and TG >1.7 mmol/L. Comparable groupings were created by substituting body mass index (BMI) values for TG concentration (<27.0 and ≥27.0 kg/m²).

The researchers found that 8.2 percent of the total population developed incident T2DM. There was variation in T2DM event rates (statin or placebo), from a low of 2.8 percent/3.2 percent (NFG and TG ≤1.7 mmol/L) to a high of 22.8 percent/7.6 percent (PreDM and TG >1.7 mmol/L); the values were intermediate for only elevated TG >1.7 mmol/L (5.2 percent /4.3 percent) or only PreDM (12.8 percent/7.6 percent). The differences were comparable with BMI values.

"These data suggest that the diabetogenic impact of statin treatment is relatively modest in general," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Pfizer, which funded the TNT and SPARCL clinical trials.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Caffeine Found to Reduce Age-Related Inflammation

Caffeine Found to Reduce Age-Related Inflammation

Connection between advancing age, systemic inflammation, cardiovascular disease and caffeine

Neonatal Abstinence Syndrome Tied to Poor School Performance

Neonatal Abstinence Syndrome Tied to Poor School Performance

By seventh grade, four out of 10 failed to meet standards in at least one academic area

Heart Rate Variability Linked to Atrial Fibrillation

Heart Rate Variability Linked to Atrial Fibrillation

Lower HRV, increased sympathetic/parasympathetic tone linked to higher risk of a-fib

is free, fast, and customized just for you!

Already a member?

Sign In Now »