In Breast CA, Cardiotoxicity Up With Trastuzumab-Based Chemo

This article originally appeared here.
Share this content:
In Breast CA, Cardiotoxicity Up With Trastuzumab-Based Chemo
In Breast CA, Cardiotoxicity Up With Trastuzumab-Based Chemo

WEDNESDAY, April 20, 2016 (HealthDay News) -- For adult women with breast cancer, trastuzumab-based regimens are associated with increased risk of cardiotoxicity, according to a study published online April 18 in the Journal of Clinical Oncology.

In an effort to examine the risk of cardiotoxicity with breast cancer therapy, Paaladinesh Thavendiranathan, M.D., from Toronto General Hospital, and colleagues conducted a population-based retrospective cohort study involving 14 regional cancer centers. A total of 18,540 adult women (median age, 54 years) receiving chemotherapy for stage I to III breast cancer between 2007 and 2012 were included.

The researchers found that the primary outcome (a composite of hospitalization or emergency room visit for congestive heart failure [CHF], outpatient diagnosis of CHF, or cardiovascular death) had a cumulative incidence of 3.08 percent by three years of follow-up, compared with 0.96 percent in an age-matched sample of 92,700 Ontario women without breast cancer. Patients receiving trastuzumab with nonanthracycline chemotherapy and sequential therapy had increased risk of cardiotoxicity compared with those receiving other chemotherapy (hazard ratios, 1.76 and 3.96, respectively). With sequential therapy only, hospital-based CHF events were increased (hazard ratio, 1.86).

"In women with breast cancer and an age distribution representative of routine clinical practice, trastuzumab-based regimens, including those without anthracyclines, were associated with an increased risk of cardiotoxicity," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

CDC: Too Many Health Care Workers Not Getting Flu Vaccine

CDC: Too Many Health Care Workers Not Getting ...

Vaccination protects both workers and patients

Early Mobilization Improves Outcomes, LOS in Surgical ICUs

Early Mobilization Improves Outcomes, LOS in Surgical ICUs

Patients discharged sooner, become more functional when they leave the hospital

is free, fast, and customized just for you!

Already a member?

Sign In Now »