In Acetaminophen-Induced Acute Liver Failure, FABP1 IDs Mortality

Share this content:
In Acetaminophen-Induced Acute Liver Failure, FABP1 IDs Mortality
In Acetaminophen-Induced Acute Liver Failure, FABP1 IDs Mortality

MONDAY, Nov. 28, 2016 (HealthDay News) -- Serum liver-type fatty acid binding protein (FABP1) early (day one) or late (day three to five) levels are associated with mortality in patients with acetaminophen (APAP)-induced acute liver failure (ALF), according to a study published online Nov. 18 in Hepatology.

Constantine J. Karvellas, M.D., from the University of Alberta in Edmonton, Canada, and colleagues examined whether FABP1 early or late levels are associated with 21-day mortality in the absence of liver transplant. Serum samples were analyzed from 198 APAP-ALF patients (99 survivors and 99 non-survivors).

The researchers found that serum FABP1 levels were significantly lower for APAP-ALF survivors versus non-survivors early and late (both P < 0.0001). FABP1 >350 ng/mL correlated with elevated risk of death at early and late time points (P = 0.0004 and P < 0.0001, respectively). After adjustment for significant covariates, increased serum FABP1 early and late correlated with significantly increased 21-day mortality (odds ratios, 1.31 [P = 0.027] and 1.50 [P = 0.005], respectively). For early and late multivariable models, areas under the receiver-operating curve (AUROC) were 0.778 and 0.907, respectively. The addition of FABP1 significantly improved the AUROC of the King's College Criteria and Acute Liver Failure Study Group prognostic index.

"In patients with APAP-ALF, FABP1 may have good potential to discriminate survivors from non-survivors and may improve models currently used in clinical practice," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Gene Tx Approved for Certain Types of B-Cell Lymphoma

Gene Tx Approved for Certain Types of B-Cell ...

First such treatment for certain types of non-Hodgkin lymphoma

Uninsurance Down by One-Third for Cancer Diagnoses in 2014

Uninsurance Down by One-Third for Cancer Diagnoses in ...

Significant decreases in uninsurance seen across all stages and sites assessed in first year of ACA

Diabetes Ups Risk of MACE in Acute Coronary Syndromes

Diabetes Ups Risk of MACE in Acute Coronary ...

Diabetes, but not pre-diabetes, tied to increased risk of major adverse cardiac events in adjusted model

is free, fast, and customized just for you!

Already a member?

Sign In Now »