'Ice Bucket Challenge' Led to Significant ALS Gene Discovery

This article originally appeared here.
Share this content:
'Ice Bucket Challenge' Led to Significant ALS Gene Discovery
'Ice Bucket Challenge' Led to Significant ALS Gene Discovery

WEDNESDAY, July 27, 2016 (HealthDay News) -- The hugely popular "Ice Bucket Challenge" funded a study that has discovered an important new amyotrophic lateral sclerosis (ALS) gene. The study, which involved more than 80 researchers in 11 countries, was published online July 25 in Nature Genetics.

The ALS Association used Ice Bucket Challenge donations to fund Project MinE, an international effort to sequence the genomes of at least 15,000 individuals with ALS.

Researchers now report on the fruits of that effort: The NEK1 gene was discovered through a search for ALS risk genes in 1,022 families with a history of ALS. Further gene testing, of more than 13,000 patients with ALS who did not have a family history of the disease, also revealed over-representation of variants in the NEK1 gene.

"Global collaboration among scientists, which was really made possible by ALS Ice Bucket Challenge donations, led to this important discovery," study co-leader John Landers, Ph.D., from the University of Massachusetts Medical School in Worcester, said in an ALS Association new release. "It is a prime example of the success that can come from the combined efforts of so many people, all dedicated to finding the causes of ALS. This kind of collaborative study is, more and more, where the field is headed."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Deaths, Cardiac Arrest Not Rare in Triathlon Participants

Deaths, Cardiac Arrest Not Rare in Triathlon Participants

Incidence of death or cardiac arrest 1.74 per 100,000 participants; higher incidence in men, with age

ACP Does Not Support Legalization of Assisted Suicide

ACP Does Not Support Legalization of Assisted Suicide

Legalization would affect trust in the patient-physician relationship, and in the medical profession

AAP: Epinephrine Admin Training Needed in Many Schools

AAP: Epinephrine Admin Training Needed in Many Schools

In 2015 to 2016, 2.7 percent reported that epinephrine was administered by unlicensed staff

is free, fast, and customized just for you!

Already a member?

Sign In Now »