IBD Associated With Increased Risk of Parkinson's Disease

Share this content:
IBD Associated With Increased Risk of Parkinson's Disease
IBD Associated With Increased Risk of Parkinson's Disease

TUESDAY, May 22, 2018 (HealthDay News) -- There is a significantly increased risk of Parkinson's disease (PD) in patients with inflammatory bowel disease (IBD), according to a study published online May 21 in Gut.

Marie Villumsen, Ph.D., from Bispebjerg and Frederiksberg Hospital in Copenhagen, Denmark, and colleagues used data from a nationwide population-based cohort study involving all individuals diagnosed with IBD in Denmark between 1977 and 2014 (76,477 participants) and non-IBD individuals (7,548,259 participants) who were comparable in terms of age, gender, and vital status. Comparisons were made between the groups for the incidence of PD and multiple system atrophy (MSA).

The researchers found that patients with IBD had a 22 percent increased risk of PD versus non-IBD individuals (hazard ratio, 1.22; 95 percent confidence interval, 1.09 to 1.35), which persisted regardless of age at IBD diagnosis, gender, or length of follow-up. The overall incidence of MSA was low, with a trend toward higher risk of MSA in patients with IBD versus non-IBD individuals (hazard ratio, 1.41; 95 percent confidence interval, 0.82 to 2.44). Furthermore, an increased risk of parkinsonism was seen in patients with ulcerative colitis (hazard ratio, 1.35; 95 percent confidence interval, 1.2 to 1.52) but not Crohn's disease (hazard ratio, 1.12; 95 percent confidence interval, 0.89 to 1.4).

"This nationwide, unselected, cohort study shows a significant association between IBD and later occurrence of PD, which is consistent with recent basic scientific findings of a potential role of gastrointestinal inflammation in development of parkinsonian disorders," the authors write.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »