Hypermutated ctDNA Linked to Checkpoint Inhibitor Response

Share this content:
Hypermutated ctDNA Linked to Checkpoint Inhibitor Response
Hypermutated ctDNA Linked to Checkpoint Inhibitor Response

MONDAY, Oct. 2, 2017 (HealthDay News) -- For patients with diverse malignancies, hypermutated blood-derived circulating tumor DNA (ctDNA) is associated with checkpoint inhibitor response, according to a study published online Oct. 2 in Clinical Cancer Research.

Yulian Khagi, M.D., from the University of California San Diego Moores Cancer Center in La Jolla, and colleagues assessed 69 patients with diverse malignancies who received checkpoint inhibitor-based immunotherapy and blood-derived ctDNA next-generation sequencing testing of 54 to 70 genes. Based on total and variants of unknown significance (VUS) alterations, the rates of stable disease for at least six months, partial and complete response (PR and CR), progression-free survival (PFS), and overall survival (OS) were assessed.

The researchers found that significant improvement in PFS was seen for high versus low alteration number in VUS (greater than three versus three or fewer alterations), with stable disease for at least six months/PR/CR of 45 and 15 percent, respectively. The results were similar for high versus low total alteration number (characterized plus VUS, greater than or equal to six versus fewer than six). High VUS alteration status also correlated with statistically significant OS improvement. Responders versus nonresponders with VUS greater than three had a median PFS of 23 versus 2.3 months in two-month landmark analysis.

"Given the association of alteration number on liquid biopsy and checkpoint inhibitor-based immunotherapy outcomes, further investigation of hypermutated ctDNA as a predictive biomarker is warranted," the authors write.

Several authors disclosed financial ties to the biopharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

Housing Instability Linked to Poor Caregiver, Child Health

Housing Instability Linked to Poor Caregiver, Child Health

Outcomes similar for being behind on rent, multiple moves within a year, homelessness

No Maintenance Period Seen After Weight Loss Plan Completed

No Maintenance Period Seen After Weight Loss Plan ...

Weight regain may begin immediately after weight management program ends

Public Health Workforce to See Large Turnover

Public Health Workforce to See Large Turnover

Significant percentage could leave workforce by 2020; public sector faces recruitment challenges

is free, fast, and customized just for you!

Already a member?

Sign In Now »