HSPC-Derived CAR T-Cells Capable of Lasting Engraftment

Share this content:
HSPC-Derived CAR T-Cells Capable of Lasting Engraftment
HSPC-Derived CAR T-Cells Capable of Lasting Engraftment

WEDNESDAY, Jan. 3, 2018 (HealthDay News) -- Hematopoietic stem/progenitor cell (HSPC)-derived chimeric antigen receptor (CAR) T-cells are capable of long-term engraftment in a model of HIV/AIDS, according to a study published online Dec. 28 in PLOS Pathogens.

Anjie Zhen, Ph.D., from the David Geffen School of Medicine at the University of California, Los Angeles, and colleagues reported the use of a protective CD4 CAR (C46CD4CAR) to redirect HSPC-derived T-cells against simian/human immunodeficiency virus (SHIV) infection in pigtail macaques.

The researchers found that CAR-containing cells persisted for more than two years with no measurable toxicity; they were capable of multilineage engraftment. Lower viral rebound was seen in CAR animals relative to controls with combination antiretroviral therapy (cART) treatment followed by cART withdrawal, with demonstration of an immune memory-like response. CAR-expressing cells were detected in multiple lymphoid tissues, and there were reduced tissue-associated SHIV RNA levels and higher CD4/CD8 ratios in the gut relative to controls.

"These results show that HSPC-derived CAR T-cells are capable of long-term engraftment and immune surveillance," the authors write. "This study demonstrates for the first time the safety and feasibility of HSPC-based CAR therapy in a large animal preclinical model."

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Medicare Requiring Hospitals to Post Prices Online

Medicare Requiring Hospitals to Post Prices Online

Medicare would base part of a hospital's payments on how easy it is for patients to access medical records

Restless Brain Syndrome Tied to Changes in the Brain

Restless Brain Syndrome Tied to Changes in the ...

Morphological differences seen in the primary somatosensory system

People With Opioid Use Disorder Have High Suicide Rate

People With Opioid Use Disorder Have High Suicide ...

Based on data from multiple sources, many opioid-overdose deaths seem to be suicides

is free, fast, and customized just for you!

Already a member?

Sign In Now »