HSCT No Better Than Chemo in Philadelphia-Negative ALL

This article originally appeared here.
Share this content:
HSCT No Better Than Chemo in Philadelphia-Negative ALL
HSCT No Better Than Chemo in Philadelphia-Negative ALL

THURSDAY, June 2, 2016 (HealthDay News) -- For patients ≥40 years of age with Philadelphia (Ph)-negative acute lymphoblastic leukemia (ALL), hematopoietic stem-cell transplantation (HSCT) in first remission is associated with lower cumulative incidence of relapse (CIR), but worse non-relapse mortality (NRM), compared with chemotherapy alone, according to a study published online May 6 in the American Journal of Hematology.

Ofir Wolach, M.D., from the Dana-Farber Cancer Institute in Boston, and colleagues examined whether HSCT in first remission confers a survival benefit versus chemotherapy alone in patients ≥40 years of age with Ph-negative ALL. The outcome of patients treated with HSCT or chemotherapy alone in first remission (40 patients in each cohort) was compared.

The researchers observed no significant difference in three-year overall survival (OS) and disease-free survival (DFS) between the chemotherapy alone and HSCT groups (OS, 46 versus 40 percent; P = 0.35; DFS, 31 versus 40 percent; P = 0.98). The three-year CIR was 61 and 28 percent for the chemotherapy-only and HSCT groups, respectively (P = 0.011), while three-year NRM was 9 and 32 percent, respectively (P = 0.014).

"Allogeneic transplantation for patients ≥40 years with Ph-negative ALL in first remission is associated with a lower CIR but this benefit is offset by considerable NRM as compared with chemotherapy-only approach," the authors write. "HSCT may be beneficial in patients with high-risk disease features."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Factors ID'd to Predict Fatty Liver in Obese Teens

Factors ID'd to Predict Fatty Liver in Obese ...

African-American obese teens more susceptible to fatty liver effects on glucose metabolism

Patients Prefer Doctors Who Engage in Face-to-Face Visits

Patients Prefer Doctors Who Engage in Face-to-Face Visits

Patients perceive F2F physicians as more compassionate and better communicators

Flexible Sigmoidoscopy Cuts CRC Incidence, Mortality in Men

Flexible Sigmoidoscopy Cuts CRC Incidence, Mortality in Men

Absolute risks for colorectal cancer, CRC death not reduced for screening group vs. controls in women

is free, fast, and customized just for you!

Already a member?

Sign In Now »