hs-CRP Predicts Depression Treatment Response in T1DM

Share this content:
hs-CRP Predicts Depression Treatment Response in T1DM
hs-CRP Predicts Depression Treatment Response in T1DM

TUESDAY, Aug. 9, 2016 (HealthDay News) -- Higher baseline high-sensitivity C-reactive protein (hs-CRP) is associated with less treatment-linked improvement in depression in patients with type 1 diabetes, according to a study published online Aug. 3 in Diabetes Care.

Daniela Zahn, Ph.D., from the Johannes Gutenberg University Mainz in Germany, and colleagues examined the correlation between hs-CRP and depression in patients with diabetes. Participants with diabetes and major depression undergoing depression treatment were randomized to 12 weeks of diabetes-specific group cognitive behavioral therapy or sertraline treatment and followed for 15 months. In 219 patients, hs-CRP was assessed at baseline and at the end of the long-term phase.

The researchers found that even after adjustment for confounders there were significant interactions between baseline hs-CRP and diabetes type for short- and long-term improvement in depression. Higher baseline hs-CRP correlated with less improvement in type 1 diabetes, but there was no significant correlation in type 2 diabetes.

"In a large sample of patients with poorly controlled diabetes, we found evidence that higher baseline hs-CRP predicts poorer outcomes of depression treatment in type 1 diabetes," the authors write. "Although hs-CRP appeared to be less relevant in type 2 diabetes, including other markers of inflammation as suggested by others may be necessary to determine the role of inflammation and depression outcomes in this group."

Several authors disclosed financial ties to the pharmaceutical industry.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions


Sign up for myCME e-newsletters


More in Home

Automated Central System Offers Time Savings for Pharmacists

Automated Central System Offers Time Savings for Pharmacists

Cart-fill process using new automated system is more efficient, frees up time for other roles

Therapeutic Horseback Riding Can Help Alleviate PTSD in Veterans

Therapeutic Horseback Riding Can Help Alleviate PTSD in ...

Study found statistically and clinically significant reduction in PTSD scores after six weeks of THR

Bariatric Surgery Linked to Discontinuing Diabetes Meds

Bariatric Surgery Linked to Discontinuing Diabetes Meds

Six-year antidiabetes treatment initiation rate also much lower after bariatric surgery

is free, fast, and customized just for you!

Already a member?

Sign In Now »