HOMA2-IR Tied to Hepatocellular Carcinoma Risk in Hepatitis B

Share this content:
HOMA2-IR Tied to Hepatocellular Carcinoma Risk in Hepatitis B
HOMA2-IR Tied to Hepatocellular Carcinoma Risk in Hepatitis B

FRIDAY, Nov. 18, 2016 (HealthDay News) -- Insulin resistance assessed by homeostasis model assessment index (HOMA2-IR) correlates with the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection, according to a study published online Nov. 11 in the Journal of Gastroenterology and Hepatology.

Jung Hee Kim, from the Sungkyunkwan University School of Medicine in Seoul, South Korea, and colleagues examined whether HOMA2-IR can stratify HCC risk in a retrospective cohort of 1,696 patients with chronic HBV.

The researchers found that 1.4 percent of patients developed HCC. The incidence rate of HCC was higher for patients with higher versus lower HOMA2-IR values (1.7 versus 0.5 percent for HOMA2-IR >1.200 versus ≤1.200; P = 0.009). In a multivariable model adjusted for age, sex, cirrhosis, and HBV DNA levels, HOMA2-IR was a significant factor associated with HCC development (hazard ratio, 3.25; 95 percent confidence interval, 1.13 to 9.31). The correlation was attenuated after further adjustment for obesity, hypertension, and diabetes (hazard ratio, 1.93; 95 percent confidence interval, 0.57 to 6.51). In patients without overt metabolic abnormalities (hypertension, diabetes, and metabolic syndrome), but not in those with overt metabolic abnormalities, HOMA2-IR was an independent factor associated with HCC.

"HOMA2-IR was associated with the risk of HCC, indicating that HOMA2-IR can be a useful tool for stratifying the risk of HCC in chronic HBV-infected patients, particularly in patients without overt metabolic abnormalities," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Warns Against Children Taking Codeine, Tramadol

FDA Warns Against Children Taking Codeine, Tramadol

Agency strengthens warning labels on these medications to address dangers

Trump Administration Offers Grants to Fight Opioid Crisis

Trump Administration Offers Grants to Fight Opioid Crisis

Money to be used to train health professionals, foster prescription drug monitoring programs

NYC to Raise Cigarette Prices to Highest in the United States

NYC to Raise Cigarette Prices to Highest in ...

Price of pack to jump from $10.50 to $13.00

is free, fast, and customized just for you!

Already a member?

Sign In Now »