HMI Impulses From Ultrasound Transducer Beneficial in STEMI

Share this content:
HMI Impulses From Ultrasound Transducer Beneficial in STEMI
HMI Impulses From Ultrasound Transducer Beneficial in STEMI

FRIDAY, May 27, 2016 (HealthDay News) -- High mechanical index (HMI) impulses from a diagnostic ultrasound (DUS) transducer during intravenous microbubble infusion can prevent microvascular obstruction in ST-segment elevation myocardial infarction (STEMI), according to a study published in the May 31 issue of the Journal of the American College of Cardiology.

Wilson Mathias Jr., M.D., from the University of São Paulo Medical School in Brazil, and colleagues randomized patients arriving with their first STEMI to DUS intermittent HMI impulses just before and after emergent percutaneous coronary intervention (PCI) (HMI + PCI; 20 patients) or to low mechanical index (LMI) imaging before and after PCI (LMI + PCI; 10 patients). Seventy patients arrived outside the time window of ultrasound availability and received PCI only.

The researchers found that the median door-to-dilation times did not differ significantly between the groups. Angiographic recanalization prior to PCI occurred in 60, 10, and 23 percent of the HMI + PCI, LMI + PCI, and PCI-only groups, respectively (P = 0.002). No differences were seen in microvascular obstructed segments prior to treatment; at one month there were significantly smaller proportions of obstructed segments in the HMI + PCI group (P = 0.001) and significant improvements in left ventricular ejection fraction (P < 0.005).

"HMI impulses from a diagnostic transducer, combined with a commercial microbubble infusion, can prevent microvascular obstruction and improve functional outcome when added to the contemporary PCI management of acute STEMI," the authors write.

Two authors disclosed financial ties to the pharmaceutical and medical device industries.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions


Sign up for myCME e-newsletters


More in Home

ASH: Anti-CD19 CAR T-Cell Tx Beneficial in B-Cell Lymphomas

ASH: Anti-CD19 CAR T-Cell Tx Beneficial in B-Cell ...

Second study shows benefit in relapsed or refractory B-cell lymphoma, follicular lymphoma

ASH: AAVD Beats ABVD for Advanced Hodgkin's Lymphoma

ASH: A&#43;AVD Beats ABVD for Advanced Hodgkin's Lymphoma

Lower combined risk of progression, death, or noncomplete response with A+AVD

ASH: High-Dose Gene Transfer Beneficial in Severe Hemophilia A

ASH: High-Dose Gene Transfer Beneficial in Severe Hemophilia ...

Factor VIII gene transfer tied to sustained normalization of factor VIII activity levels

is free, fast, and customized just for you!

Already a member?

Sign In Now »