HIV Active in Tissues Even in Patients on Antiretrovirals

This article originally appeared here.
Share this content:
HIV Active in Tissues Even in Patients on Antiretrovirals
HIV Active in Tissues Even in Patients on Antiretrovirals

THURSDAY, Oct. 27, 2016 (HealthDay News) -- For patients taking antiretroviral medications, HIV continues to reside in tissues, and though this may not cause AIDS, it could contribute to the development of unrelated conditions such as cancer and cardiovascular disease, according to research published in the October issue of the Journal of Virology.

Michael McGrath, M.D., Ph.D., a University of California, San Francisco, professor of laboratory medicine at the AIDS and Cancer Specimen Resource, and colleagues analyzed autopsy tissue samples from five HIV patients who took antiretrovirals and found undetectable levels of the virus in their blood.

However, the researchers did find that the virus had evolved and migrated to brain, kidney, spleen, and other tissues similar to the way it does in HIV patients who don't take antiretrovirals. It's possible that active, untreated virus in tissues could be driving diseases unrelated to AIDS "that are increasingly the cause of death for virally suppressed patients," McGrath said in a university news release.

"Our results suggest that HIV in varied tissue compartments can be untouched by the medications," McGrath added. "In addition, our findings suggest that strategies to 'cure' HIV infection, which are centered on treatment of blood, must consider targeting tissue-based sites of HIV."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

Adding HIPEC to Cytoreductive Surgery Beneficial in Ovarian CA

Adding HIPEC to Cytoreductive Surgery Beneficial in Ovarian ...

Longer survival with hyperthermic intraperitoneal chemotherapy in stage III epithelial ovarian cancer

Chaplains Effective in Facilitating Advance Care Planning

Chaplains Effective in Facilitating Advance Care Planning

80 percent of patients who met chaplains in medical practice completed or provided advance directive

Alzheimer's Disease Variants Linked to Brain Amyloidosis

Alzheimer's Disease Variants Linked to Brain Amyloidosis

Significant correlations found for adenosine triphosphate-binding cassette subfamily A member

is free, fast, and customized just for you!

Already a member?

Sign In Now »