Higher CRC Risk With Advanced Adenoma Found on Colonoscopy

Share this content:
Higher CRC Risk With Advanced Adenoma Found on Colonoscopy
Higher CRC Risk With Advanced Adenoma Found on Colonoscopy

WEDNESDAY, May 16, 2018 (HealthDay News) -- Participants with an advanced adenoma at diagnostic colonoscopy have increased risk of developing colorectal cancer (CRC) relative to those with no adenoma, according to a study published in the May 15 issue of the Journal of the American Medical Association.

Benjamin Click, M.D., from the University of Pittsburgh, and colleagues conducted a multicenter, prospective cohort study involving participants in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer randomized clinical trial of flexible sigmoidoscopy (FSG). Data were included for 154,900 men and women enrolled in PLCO, of whom 15,935 underwent colonoscopy after their first positive FSG screening result.

The researchers found that on initial colonoscopy, 18.1, 31.8, and 50.1 percent of participants had an advanced adenoma, a non-advanced adenoma, and no adenoma, respectively; the median follow-up for CRC incidence was 12.9 years. Per 10,000 person-years of observation, the incidence rates of CRC were 20, 9.1, and 7.5 for advanced adenoma, non-advanced adenoma, and no adenoma, respectively. Compared to participants with no adenoma, those with advanced adenoma were significantly more likely to develop CRC (rate ratio, 2.7; 95 percent confidence interval, 1.9 to 3.7; P < 0.001). No significant difference in CRC risk was seen for participants with non-advanced adenoma versus those with no adenoma (rate ratio, 1.2; 95 percent confidence interval, 0.8 to 1.7; P = 0.3).

"Identification of non-advanced adenoma may not be associated with increased colorectal cancer risk," the authors write.

One author disclosed financial ties to Medtronic.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

FDA OKs Doptelet for Liver Dz Patients Undergoing Procedures

FDA OKs Doptelet for Liver Dz Patients Undergoing ...

Doptelet reduces the need for platelet transfusion or any rescue therapy on day of procedure

Slower Decline in Lung Function With Anthocyanin Intake

Slower Decline in Lung Function With Anthocyanin Intake

Slower annual rates of decline in FEV1 and FVC for those in highest quartile of anthocyanin intake

Bioengineering Feasible for Airway Reconstruction

Bioengineering Feasible for Airway Reconstruction

Bioengineered tracheal and bronchial reconstruction reported using stented aortic matrices

is free, fast, and customized just for you!

Already a member?

Sign In Now »