High Salt Intake Impacts Gut Microbiome

Share this content:
High Salt Intake Impacts Gut Microbiome
High Salt Intake Impacts Gut Microbiome

MONDAY, Nov. 20, 2017 (HealthDay News) -- High salt intake affects the gut microbiome; however, certain intestinal bacteria may help prevent high-salt diets contributing to hypertension, according to research published online Nov. 15 in Nature.

Nicola Wilck, M.D., from Charité-Universitätsmedizin Berlin, and colleagues used gene sequencing to analyze fecal pellets from mice in order to determine the effect of a high-salt diet on the composition of the gut microbiome. Mice were fed a normal-salt diet or a high-salt diet to mimic the western lifestyle.

The researchers found that high salt intake affected the gut microbiome in mice, particularly by depleting Lactobacillus murinus. By modulating T helper 17 (TH17) cells, treatment of mice with L. murinus prevented salt-induced aggravation of actively induced experimental autoimmune encephalomyelitis and salt-sensitive hypertension. Similarly, in a human pilot study, a moderate high-salt challenge reduced intestinal survival of Lactobacillus spp., increased TH17 cells, and increased blood pressure.

"Our results connect high salt intake to the gut-immune axis and highlight the gut microbiome as a potential therapeutic target to counteract salt-sensitive conditions," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions


Sign up for myCME e-newsletters


More in Home

ASH: Anti-CD19 CAR T-Cell Tx Beneficial in B-Cell Lymphomas

ASH: Anti-CD19 CAR T-Cell Tx Beneficial in B-Cell ...

Second study shows benefit in relapsed or refractory B-cell lymphoma, follicular lymphoma

ASH: AAVD Beats ABVD for Advanced Hodgkin's Lymphoma

ASH: A+AVD Beats ABVD for Advanced Hodgkin's Lymphoma

Lower combined risk of progression, death, or noncomplete response with A+AVD

ASH: High-Dose Gene Transfer Beneficial in Severe Hemophilia A

ASH: High-Dose Gene Transfer Beneficial in Severe Hemophilia ...

Factor VIII gene transfer tied to sustained normalization of factor VIII activity levels

is free, fast, and customized just for you!

Already a member?

Sign In Now »