High Prevalence of Allergic Sensitization in Pediatric Asthma

This article originally appeared here.
Share this content:
High Prevalence of Allergic Sensitization in Pediatric Asthma
High Prevalence of Allergic Sensitization in Pediatric Asthma

THURSDAY, Sept. 22, 2016 (HealthDay News) -- Among children with persistent asthma, the prevalence of allergic sensitization is high, according to a study published online Sept. 17 in Allergy.

Annica Önell, Ph.D., from Microtest Dx in London, and colleagues examined the accuracy of and information obtained by two microarray platforms applied on a pediatric asthma cohort. Seventy-one children from a Swedish study were recruited, of whom 40 and 31 had severe and controlled asthma, respectively. Participants were assessed for allergic sensitization by two microarray systems and by two standard diagnostic methods.

The researchers observed a high prevalence of allergic sensitization in the cohort. Independently of the methods compared, the pairwise concordance between two methods was 90 to 92 percent. The sensitivity and specificity of the four methods against doctor's diagnosis was 0.77 to 0.88 and 0.97 to 0.99, respectively. In 47 percent of the sensitized children, microarray methods provided new information compared with results obtained by standard diagnostic methods.

"The high prevalence of food and respiratory sensitization supports the clinical guideline recommendation that allergies should be evaluated in all children with suspected asthma," the authors write. "The microarray platforms studied here demonstrated acceptable accuracy and provided refined immunoglobulin E characterization in 47 percent of the patients compared to standard extract-based methods."

Three authors are employees of Microtest Dx, which makes one of the microarray systems used in the study.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

USPSTF Urges Abuse Screening for Reproductive-Aged Women

USPSTF Urges Abuse Screening for Reproductive-Aged Women

Evidence lacking for assessing balance of benefits, harms of screening for abuse of seniors, vulnerable

Five-Day Nitrofurantoin Beats Single-Dose Fosfomycin for UTI

Five-Day Nitrofurantoin Beats Single-Dose Fosfomycin for UTI

Increased likelihood of clinical and microbiological resolution for uncomplicated UTI in women

Exercise Intervention Doesn't Improve Walking Ability in PAD

Exercise Intervention Doesn't Improve Walking Ability in PAD

Smaller mean change from baseline to follow-up in 6-minute walking distance with exercise intervention

is free, fast, and customized just for you!

Already a member?

Sign In Now »