Herbal, Dietary Supplements Cause One-Fifth of Hepatotoxicity

Share this content:
Herbal, Dietary Supplements Cause One-Fifth of Hepatotoxicity
Herbal, Dietary Supplements Cause One-Fifth of Hepatotoxicity

TUESDAY, Oct. 18, 2016 (HealthDay News) -- Herbal and dietary supplement (HDS)-induced liver injury accounts for 20 percent of cases of hepatotoxicity in the United States, according to research published online Sept. 27 in Hepatology.

Victor Navarro, M.D., from Einstein Healthcare Network in Philadelphia, and colleagues examine the current challenges in the diagnosis and management of HDS-induced liver injury.

The researchers note that HDS-induced liver injury accounts for one in five cases of hepatotoxicity in the United States. Anabolic steroids, green tea extract, and multi-ingredient nutritional supplements (MINS) are the major implicated agents. Anabolic steroids, which are marketed as bodybuilding supplements, tend to induce a prolonged cholestatic, self-limiting liver injury, characterized by a distinctive biochemical and histological phenotype. In contrast, green tea extracts and other products cause an acute hepatitis-like injury. MINS account for most cases of HDS-associated liver injury; the causative agent is usually unknown or can only be suspected.

"The confident identification of injurious ingredients within HDS will require strategic alignments among clinicians, chemists, and toxicologists," the authors write. "The ultimate goal should be to prohibit or more closely regulate potentially injurious ingredients and thus promote public safety."

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Pace of Influenza Activity Picking Up Across the United States

Pace of Influenza Activity Picking Up Across the ...

Dominant strain right now is H3N2, CDC epidemiologist notes

Artificial Sweetener Use Up in U.S. Children in Recent Years

Artificial Sweetener Use Up in U.S. Children in ...

Consumption of low-calorie sweeteners rose from 8.7 to 25.1 percent from 1999 to 2012

Fecal Transplant No Better Than Oral Antibiotic for C. difficile

Fecal Transplant No Better Than Oral Antibiotic for ...

In direct comparison, researchers found no real difference between transplant, antibiotic treatment

is free, fast, and customized just for you!

Already a member?

Sign In Now »