Hep C Core Antigen Assays Show High Sensitivity, Specificity

Share this content:
Hep C Core Antigen Assays Show High Sensitivity, Specificity
Hep C Core Antigen Assays Show High Sensitivity, Specificity

THURSDAY, June 23, 2016 (HealthDay News) -- Testing for hepatitis C virus core antigen (HCVcAg) could be a good alternative for nucleic acid testing (NAT) for diagnosis of chronic HCV, according to a review and meta-analysis published online June 21 in the Annals of Internal Medicine.

J. Morgan Freiman, M.D., from Boston University School of Public Health, and colleagues examined the accuracy of diagnosis of active HCV infection for five HCVcAg tests versus NAT. Data were included from 44 studies that evaluated five index tests.

The researchers found that the highest quality was seen for the Abbott ARCHITECT HCV Ag assay, while the lowest quality was seen for the Ortho HCV Ag enzyme-linked immunosorbent assay (ELISA). In bivariate analyses, the sensitivity and specificity were 93.4 and 98.8 percent, respectively, for Abbott ARCHITECT; 93.2 and 99.2 percent, respectively, for Ortho ELISA; and 59.5 and 82.9 percent, respectively, for the Hunan Jynda Bioengineering Group HCV Ag ELISA. There were insufficient data regarding the Fujirebio Lumipulse Ortho HCV Ag and Eiken Lumispot HCV Ag assays. HCVcAg correlated closely with HCV RNA levels >3,000 IU/mL in three quantitative studies using Abbott ARCHITECT.

"The HCVcAg assays with signal amplification have high sensitivity, high specificity, and good correlation with HCV RNA levels greater than 3,000 IU/mL and have the potential to replace NAT in settings with high HCV prevalence," the authors write.

One author disclosed financial ties to Cepheid.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions


Sign up for myCME e-newsletters


More in Home

Structural Findings of Acute Solar Retinopathy Described

Structural Findings of Acute Solar Retinopathy Described

Patient in case study presented three days after viewing solar eclipse

Telomere Fusions Predict Dysplasia, Invasive Pancreatic CA

Telomere Fusions Predict Dysplasia, Invasive Pancreatic CA

Telomere fusions are detected in later stages of intraductal papillary mucinous neoplasm progression

Prenatal Sugar Intake May Increase Asthma Risk in Offspring

Prenatal Sugar Intake May Increase Asthma Risk in ...

Higher intake during pregnancy, in early childhood associated with childhood asthma development

is free, fast, and customized just for you!

Already a member?

Sign In Now »