Guidance for Coronary Patients With ASA/NSAID Sensitivity

Share this content:
Guidance for Coronary Patients With ASA/NSAID Sensitivity
Guidance for Coronary Patients With ASA/NSAID Sensitivity

MONDAY, Oct. 24, 2016 (HealthDay News) -- In patients with stable chronic ischemic heart disease (CIHD) and histories of nonsevere hypersensitivity reactions to acetylsalicylic acid (ASA)/nonsteroidal anti-inflammatory drugs (NSAIDs), an ASA challenge is recommended, according to a study published online Oct. 12 in Allergy.

Gabriele Cortellini, M.D., from Rimini Hospital in Italy, and colleagues analyzed data on ASA challenges and desensitizations from 10 allergy centers (310 patients) and sought consensus from physicians and an expert panel to determine clinical criteria for eligibility for an ASA challenge and/or desensitization in coronary artery disease patients with hypersensitivity to ASA.

The researchers found that 119 of the 310 subjects had index reactions to ASA doses lower than 300 mg. Of the 138 with acute coronary syndrome (ACS), 101 underwent desensitizations. Of the 172 with CIHD, 126 underwent challenges. In all, 163 subjects underwent challenges and 147 underwent desensitizations; in the latter group, 86 had index reactions to ASA doses of 300 mg or less. Ten subjects reacted to challenges (seven at doses ≤500 mg; three at a cumulative dose of 110 mg). The desensitization failure rate was 1.4 percent.

"In patients with stable CIHD and histories of non-severe hypersensitivity reactions to ASA/NSAIDs, an ASA challenge is advisable," the authors write. "Patients with an ACS and histories of hypersensitivity reactions to ASA, especially following doses lower than 100 mg, should directly undergo desensitization."

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Better Stem Cell Tx Outcomes for Younger MS Patients

Better Stem Cell Tx Outcomes for Younger MS ...

Results support additional trials of autologous hematopoietic stem cell transplantation

OD Risk Up in Children Whose Mothers Are Prescribed Opioids

OD Risk Up in Children Whose Mothers Are ...

Second study finds opioids stored unsafely in many households with children

AAP Urges Doctors Not to Punish Pregnant Women for Opioid Use

AAP Urges Doctors Not to Punish Pregnant Women ...

Group says better prevention and treatment, not jail time, would stem surge in drug-addicted newborns

is free, fast, and customized just for you!

Already a member?

Sign In Now »