Grapefruit-Midazolam Interaction Varies With Juice Characteristics

This article originally appeared here.
Share this content:
Grapefruit-Midazolam Interaction Varies With Juice Characteristics
Grapefruit-Midazolam Interaction Varies With Juice Characteristics

FRIDAY, Aug. 12, 2016 (HealthDay News) -- The interaction between grapefruit juice and midazolam varies based on grapefruit juice-related characteristics such as the amount of furanocoumarin, according to a study published online Aug. 9 in the Journal of Clinical Pharmacology.

Marina Kawaguchi-Suzuki, Pharm.D., Ph.D., from the University of Florida in Gainesville, and colleagues conducted a trial involving 12 healthy volunteers to examine the effect of regular grapefruit juice (RGJ) and a novel, low furanocoumarin hybrid grapefruit juice (HGJ) on the metabolism of oral midazolam, compared with water as a control.

The researchers found that the point estimate for the RGJ/water midazolam area under the curve (AUC) geometric mean ratio was 1.22 percent. The point estimate for the HGJ/water midazolam AUC ratio was within the bioequivalence range of 80 to 125 percent, indicating no interaction. In a systematic review of the evidence of the pharmacokinetic alteration of midazolam by grapefruit juice, most studies showed alteration in midazolam pharmacokinetics, supporting CYP3A activity inhibition as a likely mechanism; however, there was wide variation in the cohorts included and extent of pharmacokinetic interaction.

"The current study indicated grapefruit juice-drug interaction varies substantially based on patient characteristics and/or grapefruit juice product-related factors, including the amount of furanocoumarin constituents present in the juice," the authors write.

One author was an inventor on patent applications for hybrid grapefruit 914.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

High Success Rates for Mitral Valve Repair With Robotic Surgery

High Success Rates for Mitral Valve Repair With ...

Minimally invasive surgery linked to fewer discharges to facility, one day less in hospital vs conservative sx

Tattoo-Linked Complications ID'd in Immunosuppressed Female

Tattoo-Linked Complications ID'd in Immunosuppressed Female

Inflammatory myopathy identified in woman with cystic fibrosis on long-term immunosuppressants

Rates of Cardiac Stress Testing Down but Still Higher in CKD

Rates of Cardiac Stress Testing Down but Still ...

Decline in rates of cardiac stress testing in Medicare beneficiaries aged ≥66 years from 2008 to 2012

is free, fast, and customized just for you!




Already a member?

Sign In Now »