Glucose Variation Doesn't Affect Microvascular Complications

Share this content:
Glucose Variation Doesn't Affect Microvascular Complications
Glucose Variation Doesn't Affect Microvascular Complications

TUESDAY, April 18, 2017 (HealthDay News) -- Measures of glycemic variability in type 1 diabetes, based on complete quarterly 7-point glucose profiles, fail to provide evidence that glycemic variability contributes to the risk of development or progression of microvascular complications beyond the influence of mean glucose levels, according to a study published online April 12 in Diabetes Care.

John M. Lachin, Sc.D., from George Washington University in Rockville, Md., and colleagues utilized data from the Diabetes Control and Complications Trial to assess the association of glucose variability within and between quarterly 7-point glucose profiles and the development and progression of retinopathy, nephropathy, and cardiovascular autonomic neuropathy.

The researchers found that adjusting for mean blood glucose, no measure of within-day variability was associated with any outcome. There was a significant association between the longitudinal mean M-value (over time) and microalbuminuria, when adjusted for the longitudinal mean blood glucose and corrected for multiple tests using the Holm procedure.

"Overall, within-day glycemic variability, as determined from quarterly glucose profiles, does not play an apparent role in the development of microvascular complications beyond the influence of the mean glucose," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

NTproBNP Levels Are Significantly Lower in Blacks

NTproBNP Levels Are Significantly Lower in Blacks

Higher NTproBNP levels linked to increased risk of death; this association did not differ by race

Data May Weigh on Pros/Cons of Expanded Care Optometry

Data May Weigh on Pros/Cons of Expanded Care ...

Majority of residents in Kentucky, Oklahoma, New Mexico live within 30 minutes of ophthalmologist

Gaps Seen Between Hearing Loss, Receipt of Medical Evaluation, Tx

Gaps Seen Between Hearing Loss, Receipt of Medical ...

About 20.6 percent of those with hearing less than excellent/good had visited doctor for hearing issues

is free, fast, and customized just for you!

Already a member?

Sign In Now »