Genomic Approach Could Aid Risk Stratification in Adults With AML

This article originally appeared here.
Share this content:
Genomic Approach Could Aid Risk Stratification in Adults With AML
Genomic Approach Could Aid Risk Stratification in Adults With AML

WEDNESDAY, Aug. 26, 2015 (HealthDay News) -- For adult patients with de novo acute myeloid leukemia (AML), persistent leukemia-associated mutations in ≥5 percent of bone marrow cells from remission samples is linked to increased risk of relapse and worse survival, according to a study published in the Aug. 25 issue of the Journal of the American Medical Association.

Jeffery M. Klco, M.D., Ph.D., from the Washington University School of Medicine in St. Louis, and colleagues examined whether genomic approaches could provide novel prognostic information for adults with de novo AML. The authors performed whole-genome or exome sequencing on samples obtained at disease presentation from 71 patients with AML treated with standard induction chemotherapy. In addition, deep digital sequencing was performed on paired diagnosis and remission samples from 50 patients: 25 from the initiation cohort and 25 additional cases.

The researchers observed no improvement in outcome assessment for analysis of comprehensive genomic data over current standard-of-care metrics. Persistent leukemia-associated mutations in at least 5 percent of bone marrow cells at remission were identified in 24 of the patients with samples at presentation and remission. These patients had significantly reduced event-free and overall survival (hazard ratios, 3.67 and 2.86, respectively). Similar findings were seen for patients with intermediate cytogenetic risk profiles (hazard ratios, 3.32 and 2.88, respectively).

"These data suggest that this genomic approach may improve risk stratification for patients with AML," the authors write.

Two authors disclosed financial ties to the biotechnology industry.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Dermatography Helps Lessen Appearance of Surgical Scars

Dermatography Helps Lessen Appearance of Surgical Scars

Pigments can restore more natural skin appearance that patients are happy with

Drug-Resistant Bacteria Live in America's Water Systems

Drug-Resistant Bacteria Live in America's Water Systems

Bacteria found in plumbing may sicken thousands each year

Deep Brain Stimulation May Improve TBI Symptoms

Deep Brain Stimulation May Improve TBI Symptoms

Deep brain stimulation appears to boost function and quality of life

is free, fast, and customized just for you!

Already a member?

Sign In Now »