Genetic Risk Score Impact on BMI Varies Across Birth Cohorts

This article originally appeared here.
Share this content:
Genetic Risk Score Impact on BMI Varies Across Birth Cohorts
Genetic Risk Score Impact on BMI Varies Across Birth Cohorts

WEDNESDAY, July 6, 2016 (HealthDay News) -- The magnitude of the association between a multilocus genetic risk score for body mass index (GRS-BMI) and BMI is larger for individuals born in later birth cohorts, according to a study published online July 5 in the Journal of the American Medical Association.

Stefan Walter, Ph.D., from the University of California, San Francisco, and colleagues conducted an observational study involving 8,788 adults in the U.S. Health and Retirement Study born between 1900 and 1958. Participants had up to 12 BMI assessments from 1992 to 2014. A multilocus GRS-BMI was calculated as the weighted sum of alleles of 29 single-nucleotide polymorphisms associated with BMI.

The researchers found that among 7,482 white participants and 1,306 black participants, GRS-BMI was significantly correlated with BMI. GRS-BMI accounted for 0.99 and 1.37 percent of the variation in BMI in white and black participants, respectively. More recent birth cohorts had a larger magnitude of the associations of GRS-BMI with BMI in multilevel models accounting for age. Among white participants, each unit higher GRS-BMI correlated with a difference in BMI of 1.37 and 0.17 if born after 1943 and before 1924, respectively. For black participants, the corresponding values were 3.7 and 1.44, respectively.

"This suggests that associations of known genetic variants with BMI may be modified by obesogenic environments," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Post-Deployment Screening Has Limited Benefit in U.K. Military

Post-Deployment Screening Has Limited Benefit in U.K. Military

Screening based on tailored advice does not reduce prevalence of disorders or increase help-seeking

Excess BMI Ups Risk of T1DM in Autoantibody-Positive Relatives

Excess BMI Ups Risk of T1DM in Autoantibody-Positive ...

Increased diabetes progression risk occurred at lower cumulative excess BMI index in children <12

Baricitinib Associated With Significant Improvement in RA

Baricitinib Associated With Significant Improvement in RA

Findings versus placebo, adalimumab in patients non-responsive to methotrexate

is free, fast, and customized just for you!

Already a member?

Sign In Now »