Genetic Increase in SBP Linked to Risk of Type 2 Diabetes

Share this content:
Genetic Increase in SBP Linked to Risk of Type 2 Diabetes
Genetic Increase in SBP Linked to Risk of Type 2 Diabetes

TUESDAY, Oct. 11, 2016 (HealthDay News) -- An increase in systolic blood pressure (SBP) due to genetic variants is associated with increased risk of type 2 diabetes, according to research published online Oct. 4 in Diabetes.

Rachael C. Aikens, from Swarthmore College in Philadelphia, and colleagues examined the impact of 28 genetic variants associated with SBP on type 2 diabetes. Data were included for 37,293 cases and 125,686 controls in a Europe-centric meta-analysis.

The researchers found that a 1 mm Hg elevation of SBP levels due to the genetic score correlated with a 2 percent increase in the risk of type 2 diabetes (odds ratio, 1.02). A similar increase in the risk of type 2 diabetes was seen for a 1 mm Hg genetic elevation in SBP using a second score based on 13 variants exclusively associated with SBP (odds ratio, 1.02). In sensitivity analyses using multiple, alternative causal inference measures and simulation studies the association was found to be consistent.

"In line with previous reports from observational studies, we found that genetically elevated SBP was associated with increased risk to type 2 diabetes," the authors write. "Further work will be required to elucidate the biological mechanism and translational implications."

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Low-Dose Hyaluronidase Can Remove Hyaluronic Acid Fillers

Low-Dose Hyaluronidase Can Remove Hyaluronic Acid Fillers

Greater resolution of nodules with hyaluronidase versus saline; more rapid resolution with higher doses

Improvement in Race-Based Disparities in Years of Life Lost

Improvement in Race-Based Disparities in Years of Life ...

Decline in race-based disparities in years of life lost seen in the United States from 1990 to 2014

Drug-Related Endocarditis Cases Up From 2007 to 2015

Drug-Related Endocarditis Cases Up From 2007 to 2015

Increase in endocarditis over nine-year study period mirrored increase in concomitant mixed drug use

is free, fast, and customized just for you!

Already a member?

Sign In Now »