Genetic Increase in SBP Linked to Risk of Type 2 Diabetes

Share this content:
Genetic Increase in SBP Linked to Risk of Type 2 Diabetes
Genetic Increase in SBP Linked to Risk of Type 2 Diabetes

TUESDAY, Oct. 11, 2016 (HealthDay News) -- An increase in systolic blood pressure (SBP) due to genetic variants is associated with increased risk of type 2 diabetes, according to research published online Oct. 4 in Diabetes.

Rachael C. Aikens, from Swarthmore College in Philadelphia, and colleagues examined the impact of 28 genetic variants associated with SBP on type 2 diabetes. Data were included for 37,293 cases and 125,686 controls in a Europe-centric meta-analysis.

The researchers found that a 1 mm Hg elevation of SBP levels due to the genetic score correlated with a 2 percent increase in the risk of type 2 diabetes (odds ratio, 1.02). A similar increase in the risk of type 2 diabetes was seen for a 1 mm Hg genetic elevation in SBP using a second score based on 13 variants exclusively associated with SBP (odds ratio, 1.02). In sensitivity analyses using multiple, alternative causal inference measures and simulation studies the association was found to be consistent.

"In line with previous reports from observational studies, we found that genetically elevated SBP was associated with increased risk to type 2 diabetes," the authors write. "Further work will be required to elucidate the biological mechanism and translational implications."

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Influenza Vaccine 48 Percent Effective Overall

CDC: Influenza Vaccine 48 Percent Effective Overall

More severe H3N2 strain a factor in reduced coverage

D.C. Zika Tests Were Flawed

D.C. Zika Tests Were Flawed

One of the issues with tests was a mathematical error

Experts Warn of Health Threats From Climate Change

Experts Warn of Health Threats From Climate Change

Additional 250,000 deaths/year projected from heat stress, malnutrition, infectious diseases

is free, fast, and customized just for you!

Already a member?

Sign In Now »