Gene May ID Patients Needing Higher Doses of Methadone

Share this content:
Gene May ID Patients Needing Higher Doses of Methadone
Gene May ID Patients Needing Higher Doses of Methadone

TUESDAY, Jan. 24, 2017 (HealthDay News) -- A genetic variant associated with opioid addiction may lead to personalized treatment for the condition, according to research published online Jan. 24 in Molecular Psychiatry.

Specifically, the variant was found in black Americans affecting the gene OPRM1, which is responsible for the way opioids affect the brain. Researchers at Yale University said this may identify which blacks might require higher doses of methadone.

The researchers also said they've found that the same gene variant can predict the morphine dose required for effective pain control for black children undergoing surgery.

"We found specific gene effects in people with African ancestry, an understudied population," senior author Joel Gelernter, M.D., a professor of psychiatry, genetics and neuroscience at Yale, said in a university news release. The researchers didn't find these gene effects in people of European ancestry who had methadone treatment.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

FDA OKs Drug for Hemophilia A With Factor VIII Inhibitors

FDA OKs Drug for Hemophilia A With Factor ...

Weekly prophylactic treatment associated with substantial decrease in bleeding episodes

Risk of Falls Up With Mild, Moderate Diabetic Retinopathy

Risk of Falls Up With Mild, Moderate Diabetic ...

And perceived barriers to diabetes self-management are associated with severity of diabetic retinopathy

AMD Risk Has Dropped By Birth Cohort Throughout 20th Century

AMD Risk Has Dropped By Birth Cohort Throughout ...

Generational association remains significant after adjustment for age, sex, other confounders

is free, fast, and customized just for you!

Already a member?

Sign In Now »