Gene May ID Patients Needing Higher Doses of Methadone

Share this content:
Gene May ID Patients Needing Higher Doses of Methadone
Gene May ID Patients Needing Higher Doses of Methadone

TUESDAY, Jan. 24, 2017 (HealthDay News) -- A genetic variant associated with opioid addiction may lead to personalized treatment for the condition, according to research published online Jan. 24 in Molecular Psychiatry.

Specifically, the variant was found in black Americans affecting the gene OPRM1, which is responsible for the way opioids affect the brain. Researchers at Yale University said this may identify which blacks might require higher doses of methadone.

The researchers also said they've found that the same gene variant can predict the morphine dose required for effective pain control for black children undergoing surgery.

"We found specific gene effects in people with African ancestry, an understudied population," senior author Joel Gelernter, M.D., a professor of psychiatry, genetics and neuroscience at Yale, said in a university news release. The researchers didn't find these gene effects in people of European ancestry who had methadone treatment.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

Out-of-Pocket Expenditures Down With ACA Implementation

Out-of-Pocket Expenditures Down With ACA Implementation

Reduced out-of-pocket costs seen especially for lower-income groups; mean premium costs up overall

Gynecologic Complications Up With Hysteroscopic Sterilization

Gynecologic Complications Up With Hysteroscopic Sterilization

But lower risk of surgical and medical complications versus laparoscopic sterilization

Prevalence of Cigarette Smoking 15.5 Percent in 2016

Prevalence of Cigarette Smoking 15.5 Percent in 2016

Increase in percentage of ever smokers who quit during 2005 to 2016, from 50.8 to 59 percent

is free, fast, and customized just for you!

Already a member?

Sign In Now »