Gene Expression May Predict Response to Methotrexate in RA

This article originally appeared here.
Share this content:
Gene Expression May Predict Response to Methotrexate in RA
Gene Expression May Predict Response to Methotrexate in RA

FRIDAY, July 28, 2017 (HealthDay News) -- For patients with rheumatoid arthritis (RA), increased baseline gene expression of p21, caspase 3, and runt-related transcription factor (RUNX)2 in the peripheral blood may be associated with improved clinical response to methotrexate (MTX), according to a study published online July 25 in the International Journal of Rheumatic Diseases.

Elena V. Tchetina, Ph.D., from the Nasonova Research Institute of Rheumatology in Moscow, and colleagues examined 26 control subjects and 40 patients with RA to determine the potential of baseline gene expression in the whole blood of disease-modifying anti-rheumatic drug-naive RA patients for predicting response to MTX.

The researchers found that significant increases in joint space narrowing score (JSN) accompanied decreases in disease activity at the end of the study. Expressions of the Unc-51-like kinase1 (ULK1) and matrix metalloproteinase (MMP-9) genes were positively associated with the level of C-reactive protein; MMP-9 expression correlated with Disease Activity Score of 28 joints (DAS28) and swollen joint count. There was a positive correlation for baseline tumor necrosis factor α gene expression with JSN at the end of follow-up, while correlations were seen for p21, caspase 3, and RUNX2 with ΔDAS28 values.

"Our results suggest that the expressions of MMP-9 and ULK1 might be associated with disease activity," the authors write. "Increased baseline gene expressions of RUNX2, p21, and caspase 3 in the peripheral blood might predict better responses to MTX therapy."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Mortality Estimates Favor Annual Mammography From Age 40

Mortality Estimates Favor Annual Mammography From Age 40

Researchers estimate thousands of U.S. lives would be saved each year if mammograms started at age 40

Anti-Vaccine Info in Pregnancy May Delay Infant Immunization

Anti-Vaccine Info in Pregnancy May Delay Infant Immunization

Even if pregnant women later hear better info from doctors, they may still wait on vaccines

Hours Worked Impacted by Kids for Female, Not Male Doctors

Hours Worked Impacted by Kids for Female, Not ...

Findings from a national sample of dual-physician couples

is free, fast, and customized just for you!

Already a member?

Sign In Now »