Gastric Bypass Cuts Hormonal Responses to Hypoglycemia

Share this content:
Gastric Bypass Cuts Hormonal Responses to Hypoglycemia
Gastric Bypass Cuts Hormonal Responses to Hypoglycemia

TUESDAY, June 28, 2016 (HealthDay News) -- Gastric bypass (GBP) surgery is associated with reduced symptoms and neurohormonal responses to hypoglycemia, according to a study published online June 16 in Diabetes.

Noting that GBP patients have lowered glucose levels and frequent asymptomatic hypoglycemic episodes, Niclas Abrahamsson, M.D., Ph.D., from Uppsala University in Sweden, and colleagues examined symptoms and hormonal and autonomic nerve responses in patients exposed to hypoglycemia before and after GBP. Twelve obese patients without diabetes underwent hyperinsulinemic hypoglycemic clamp before and after GBP surgery.

The researchers found that after surgery the Edinburgh Hypoglycemia symptom delta scores during clamp were attenuated from 10.7 to 5.2. Marked reductions in glucagon, cortisol, catecholamine, and sympathetic nerve responses to hypoglycemia were seen after surgery. A delayed response was seen in growth hormones, but to a higher peak level. During hypoglycemia, glucagon-like peptide-1 and gastric inhibitory peptide increased, but to a lesser extent after surgery.

"GBP surgery causes a resetting of glucose homeostasis, which reduces symptoms and neurohormonal responses to hypoglycemia," the authors write. "Further studies should address the underlying mechanisms as well as their impact on the overall metabolic effects of GBP surgery."

The study was partially funded by Exodiab.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Pace of Influenza Activity Picking Up Across the United States

Pace of Influenza Activity Picking Up Across the ...

Dominant strain right now is H3N2, CDC epidemiologist notes

Artificial Sweetener Use Up in U.S. Children in Recent Years

Artificial Sweetener Use Up in U.S. Children in ...

Consumption of low-calorie sweeteners rose from 8.7 to 25.1 percent from 1999 to 2012

Fecal Transplant No Better Than Oral Antibiotic for C. difficile

Fecal Transplant No Better Than Oral Antibiotic for ...

In direct comparison, researchers found no real difference between transplant, antibiotic treatment

is free, fast, and customized just for you!

Already a member?

Sign In Now »