Gastric Acid Suppressants May Up Risk of Recurrent C. difficile

Share this content:
Gastric Acid Suppressants May Up Risk of Recurrent <i>C. difficile</i>
Gastric Acid Suppressants May Up Risk of Recurrent C. difficile

MONDAY, March 27, 2017 (HealthDay News) -- Use of gastric acid suppressants may increase the risk of recurrent Clostridium difficile infection (CDI), according to a meta-analysis published online March 27 in JAMA Internal Medicine.

Raseen Tariq, M.B.B.S., from the Mayo Clinic in Rochester, Minn., and colleagues conducted a systematic review and meta-analysis to examine the correlation between gastric acid suppressants and recurrent CDI. Data were included from 16 observational studies, reporting 7,703 patients with CDI.

Overall, 19.8 percent of patients with CDI developed recurrent CDI. The researchers found that the rate of recurrent CDI was 22.1 and 17.3 percent among patients with and without gastric acid suppression, respectively, indicating an increased risk by meta-analysis (odds ratio, 1.52). Significant heterogeneity was seen among the studies ( = 64 percent). After adjustment for age and potential confounders, the increased risk of recurrent CDI with use of gastric acid suppressants was confirmed (odds ratio, 1.38).

"Meta-analyses of observational studies suggest that patients who receive gastric acid suppressants may be at increased risk for recurrent CDI," the authors write. "These data should be interpreted with caution because they may be confounded owing to the observational design of the individual studies."

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Post-C-Section Cephalexin, Metronidazole Cuts SSI Rate

Post-C-Section Cephalexin, Metronidazole Cuts SSI Rate

Post-op course reduces rate of surgical site infection within 30 days of C-section among obese women

Multicomponent Intervention Linked to Greater Drop in BP

Multicomponent Intervention Linked to Greater Drop in BP

Intervention beneficial over 18 months for low-income adults in Argentina with uncontrolled HTN

Total of 0.21 Years Lost Due to Opioid-Related Poisoning Deaths

Total of 0.21 Years Lost Due to Opioid-Related ...

Drug-related poisoning deaths up from 2000 to 2015, with most of the increase due to opioid deaths

is free, fast, and customized just for you!

Already a member?

Sign In Now »