Functional Interaction Seen for Dietary Carbohydrates With AMD

This article originally appeared here.
Share this content:
Functional Interaction Seen for Dietary Carbohydrates With AMD
Functional Interaction Seen for Dietary Carbohydrates With AMD

TUESDAY, May 23, 2017 (HealthDay News) -- There may be a functional interaction between dietary carbohydrates, the metabolome, and age-related macular degeneration (AMD) features (AMDf), according to an experimental study published online May 15 in the Proceedings of the National Academy of Sciences.

Sheldon Rowan, Ph.D., from Tufts University in Boston, and colleagues examined the effect of isocaloric diets (differing only in the type of dietary carbohydrate) on AMD in a wild-type aged-mouse model.

The researchers found that consumption of a high-glycemia (HG) diet correlated with many AMDf, including retinal pigmented epithelial hypopigmentation and atrophy, accumulation of lipofuscin, and degeneration of photoreceptors; consumption of a lower-glycemia (LG) diet did not result in AMDf. Switching to the LG diet from the HG diet late in life correlated with arrest or reversal of AMDf. The accumulation of advanced glycation end products, long-chain polyunsaturated lipids, and their peroxidation end-products was limited with LG diets, and they caused increases in C3-carnitine in retina, plasma, or urine. Microbial cometabolites, especially serotonin, were protective against AMDf. Microbiota in the Clostridiales order correlated with AMDf and the HG diet, while the Bacteroidales order correlated with protection from AMDf and the LG diet.

"Our studies suggest a simple dietary intervention that may be useful in patients to arrest AMD," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

High Success Rates for Mitral Valve Repair With Robotic Surgery

High Success Rates for Mitral Valve Repair With ...

Minimally invasive surgery linked to fewer discharges to facility, one day less in hospital vs conservative sx

Tattoo-Linked Complications ID'd in Immunosuppressed Female

Tattoo-Linked Complications ID'd in Immunosuppressed Female

Inflammatory myopathy identified in woman with cystic fibrosis on long-term immunosuppressants

Rates of Cardiac Stress Testing Down but Still Higher in CKD

Rates of Cardiac Stress Testing Down but Still ...

Decline in rates of cardiac stress testing in Medicare beneficiaries aged ≥66 years from 2008 to 2012

is free, fast, and customized just for you!




Already a member?

Sign In Now »