From 2001 to 2012, Incidence of CDI, Multiply Recurrent CDI Up

Share this content:
From 2001 to 2012, Incidence of CDI, Multiply Recurrent CDI Up
From 2001 to 2012, Incidence of CDI, Multiply Recurrent CDI Up

THURSDAY, July 6, 2017 (HealthDay News) -- The annual incidence of Clostridium difficile infection (CDI) and multiply recurrent CDI (mrCDI) increased from 2001 to 2012, according to a study published online July 4 in the Annals of Internal Medicine.

Gene K. Ma, M.D., from the University of Pennsylvania Perelman School of Medicine in Philadelphia, and colleagues conducted a retrospective cohort study to examine whether the incidence of mrCDI is increasing in proportion to CDI. Data were included for 38,911,718 commercially insured patients, of whom 45,341 developed CDI.

The researchers found that from 2001 to 2012 there was an increase in the annual incidence of CDI and mrCDI by 42.7 and 188.8 percent, respectively, per 1,000 person-years. The increase in incidence of mrCDI was independent of known CDI risk factors. They also found that mrCDI development was more likely in those who were older (median age, 56.0 versus 49.0 years; adjusted odds ratio [aOR], 1.25 per 10-year increase in age), female (63.8 versus 58.7 percent; aOR, 1.24), and in those who had used antibiotics (72.3 versus 58.8 percent; aOR, 1.79), proton pump inhibitors (24.6 versus 18.2 percent; aOR, 1.14), or corticosteroids (18.3 versus 13.7 percent; aOR, 1.15) within 90 days of CDI diagnosis. Increased risk for mrCDI was also seen for chronic kidney disease (10.4 versus 5.6 percent; aOR, 1.49) and diagnosis in a nursing home (2.1 versus 0.6 percent; aOR, 1.99).

"Relative to CDI, mrCDI incidence has disproportionately increased, indicating a rising demand for mrCDI therapies," the authors write.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Mortality Estimates Favor Annual Mammography From Age 40

Mortality Estimates Favor Annual Mammography From Age 40

Researchers estimate thousands of U.S. lives would be saved each year if mammograms started at age 40

Anti-Vaccine Info in Pregnancy May Delay Infant Immunization

Anti-Vaccine Info in Pregnancy May Delay Infant Immunization

Even if pregnant women later hear better info from doctors, they may still wait on vaccines

Hours Worked Impacted by Kids for Female, Not Male Doctors

Hours Worked Impacted by Kids for Female, Not ...

Findings from a national sample of dual-physician couples

is free, fast, and customized just for you!

Already a member?

Sign In Now »