Four Methods Can Diagnose Fetal Nasal Bone Hypoplasia

This article originally appeared here.
Share this content:
Four Methods Can Diagnose Fetal Nasal Bone Hypoplasia
Four Methods Can Diagnose Fetal Nasal Bone Hypoplasia

THURSDAY, Jan. 21, 2016 (HealthDay News) -- Four methods can be used for diagnosing fetal nasal bone (NB) hypoplasia in the second trimester in order to predict Down's syndrome, according to a study published online in the February issue of the Journal of Clinical Ultrasound.

Recep Has, M.D., from Istanbul University, and colleagues examined the best method for use in diagnosing fetal NB hypoplasia in the second trimester as a means of predicting trisomy 21. They calculated and compared NB length (NBL), NBL percentiles, NBL multiple-of-median (MoM) values, and biparietal diameter-to-NBL ratios, and assessed predictive values for several cut-off points using data from 1,689 fetuses.

The researchers found that NBL had 25.5 percent sensitivity using a fixed 5 percent false-positive rate. Sensitivity for NBL percentiles, NBL MoM values, and biparietal diameter-to-NBL ratios was 23.5 percent.

"Our study demonstrated that all four methods can be used in the second trimester for diagnosing fetal NB hypoplasia as a means of predicting trisomy 21 because their predictive values are similar at a fixed 5 percent false-positive rate," the authors write. "For simplicity of use, we recommend using 3 mm as the NBL cut-off value."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists can suggest adjustments for meds taken several times per day, those affected by food intake

AUA: Many Have Unused Opioids After Urologic Procedures

AUA: Many Have Unused Opioids After Urologic Procedures

Patients use just over half of initial prescription; highest percentage of unused meds for cystectomy

Over Half of Young Adult Smoke Volume Exposure From Hookahs

Over Half of Young Adult Smoke Volume Exposure ...

Toxicant exposure to tar, carbon monoxide, nicotine lower, but still substantial, compared to cigarettes

is free, fast, and customized just for you!

Already a member?

Sign In Now »