Findings Support Bisphosphonate Use in Men With Osteoporosis

Share this content:
Findings Support Bisphosphonate Use in Men With Osteoporosis
Findings Support Bisphosphonate Use in Men With Osteoporosis

TUESDAY, Nov. 15, 2016 (HealthDay News) -- Bisphosphonates reduce the risk of vertebral, and possibly nonvertebral, fractures for men with osteoporosis, according to a review and meta-analysis published online Nov. 7 in the Journal of the American Geriatrics Society.

Smita Nayak, M.D., from the Swedish Medical Center in Seattle, and Susan L. Greenspan, M.D., from the University of Pittsburgh, conducted a systematic literature review to identify clinical trials that evaluated the efficacy of osteoporosis treatment for adult men, as well as reported fracture outcomes.

The researchers identified 24 eligible articles reporting results for 22 studies (including 4,868 male participants). Analysis showed significantly lower risk of vertebral fractures with alendronate (relative risk [RR], 0.328; 95 percent confidence interval (CI), 0.155 to 0.692) and risedronate (RR, 0.428; 95 percent CI, 0.245 to 0.746), but not with calcitonin (RR, 0.272; 95 percent CI, 0.046 to 1.608) or denosumab (RR, 0.256; 95 percent CI, 0.029 to 2.238), compared to controls. Meta-analyses showed that, as a treatment category, bisphosphonates demonstrated significantly lower risk of vertebral fractures (RR, 0.368; 95 percent CI, 0.252 to 0.537) and nonvertebral fractures (RR, 0.604; 95 percent CI, 0.404 to 0.904) versus controls. However, in sensitivity analysis, the finding that bisphosphonates significantly reduce nonvertebral fracture risk was not upheld.

"These findings support the use of bisphosphonates to reduce vertebral and possibly nonvertebral fracture risk for men with osteoporosis," the authors write.

One author disclosed financial ties to Merck.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Genital HPV Prevalence Rate High Among Men in the United States

Genital HPV Prevalence Rate High Among Men in ...

Although vaccine is recommended, too few are getting it, researchers say

17 Million U.S. Adults May Have Masked Hypertension

17 Million U.S. Adults May Have Masked Hypertension

Masked hypertension more common among males, those with diabetes, older adults

Sedentary Behavior May Lead to Shorter Telomeres in Women

Sedentary Behavior May Lead to Shorter Telomeres in ...

Cells of elderly women who sit most of the day look much older than their actual age

is free, fast, and customized just for you!

Already a member?

Sign In Now »