FGF21, Dietary Intake Interaction Impacts Adiposity

Share this content:
<i>FGF21</i>, Dietary Intake Interaction Impacts Adiposity
FGF21, Dietary Intake Interaction Impacts Adiposity

WEDNESDAY, Sept. 7, 2016 (HealthDay News) -- Fibroblast growth factor 21 (FGF21) genotypes may interact with dietary macronutrient intake to affect central adiposity and body fat composition, according to a study published online Aug. 31 in Diabetes Care.

Yoriko Heianza, from Tulane University in New Orleans, and colleagues genotyped FGF21 rs838147 in 715 overweight or obese individuals who were assigned to one of four diets with varied macronutrient contents.

The researchers observed a significant interaction between FGF21 genotype and carbohydrate/fat intake on two-year changes in waist circumference (WC) (P = 0.049), as well as percentage of fat mass and trunk fat (P = 0.001 and 0.003, respectively). Carrying the carbohydrate intake-decreasing C allele of rs838147 was marginally associated with less reduction in WC in response to the low-carbohydrate/high-fat diet (P = 0.08), and was significantly associated with less reduction of total fat mass and trunk fat (P = 0.01 and 0.02, respectively). Among the high-carbohydrate/low-fat diet group, opposite genetic associations with these outcomes were observed; carrying the C allele correlated with a greater reduction in WC, total body fat mass, and trunk fat.

"A low-calorie, high-carbohydrate/low-fat diet was beneficial for overweight or obese individuals carrying the carbohydrate intake-decreasing allele of the FGF21 variant to improve body composition and abdominal obesity," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Caffeine Found to Reduce Age-Related Inflammation

Caffeine Found to Reduce Age-Related Inflammation

Connection between advancing age, systemic inflammation, cardiovascular disease and caffeine

Neonatal Abstinence Syndrome Tied to Poor School Performance

Neonatal Abstinence Syndrome Tied to Poor School Performance

By seventh grade, four out of 10 failed to meet standards in at least one academic area

Heart Rate Variability Linked to Atrial Fibrillation

Heart Rate Variability Linked to Atrial Fibrillation

Lower HRV, increased sympathetic/parasympathetic tone linked to higher risk of a-fib

is free, fast, and customized just for you!

Already a member?

Sign In Now »