Fecal Transplant No Better Than Oral Antibiotic for C. difficile

Share this content:
Fecal Transplant No Better Than Oral Antibiotic for <i>C. difficile</i>
Fecal Transplant No Better Than Oral Antibiotic for C. difficile

FRIDAY, Jan. 13, 2017 (HealthDay News) -- A single fecal transplant delivered by enema is apparently no more effective than oral antibiotics in treating recurring cases of Clostridium difficile infection, according to research published recently in Clinical Infectious Diseases.

Susy Hota, M.D., medical director of infection prevention and control at the University Health Network in Toronto, and colleagues randomly assigned patients with recurrent C. difficile to two treatment groups. Patients in the fecal transplant group were given a 14-day course of oral vancomycin followed by a single fecal enema. The standard treatment group received a 14-day course of oral vancomycin, followed by four weeks of tapering doses of the antibiotic. Patients were followed for 120 days.

After an interim analysis, the researchers stopped the trial because the results showed no real difference in outcomes. The team found that 56.2 percent of patients who received fecal transplant and 41.7 percent of the standard treatment group experienced recurrence of C. difficile infection, which corresponded with symptom resolution in 43.8 and 58.3 percent, respectively.

"In patients experiencing an acute episode of recurrent C. difficile infection, a single fecal transplantation by enema was not significantly different from oral vancomycin taper in reducing recurrent C. difficile infection," the authors write. "Further research is needed to explore optimal donor selection, fecal transplantation preparation, route, timing, and number of administrations."

Several authors disclosed financial ties to the pharmaceutical and diagnostics industries.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Medicare Requiring Hospitals to Post Prices Online

Medicare Requiring Hospitals to Post Prices Online

Medicare would base part of a hospital's payments on how easy it is for patients to access medical records

Restless Brain Syndrome Tied to Changes in the Brain

Restless Brain Syndrome Tied to Changes in the ...

Morphological differences seen in the primary somatosensory system

People With Opioid Use Disorder Have High Suicide Rate

People With Opioid Use Disorder Have High Suicide ...

Based on data from multiple sources, many opioid-overdose deaths seem to be suicides

is free, fast, and customized just for you!

Already a member?

Sign In Now »