February 2016 Briefing - Pharmacy

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Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for February 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Analysis Reveals 'Female Libido' Pill May Not Be Worth It

MONDAY, Feb. 29, 2016 (HealthDay News) -- Flibanserin (Addyi), the "female libido" pill, appears to cause many serious side effects while failing to increase the desire for sexual activity, according to a review published online Feb. 29 in JAMA Internal Medicine.

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Late Surfactant Does Not Cut Duration of Ventilation in BPD

MONDAY, Feb. 29, 2016 (HealthDay News) -- Late administration of surfactant does not reduce the duration of ventilation in very preterm neonates with prolonged respiratory distress, according to research published online Feb. 29 in JAMA Pediatrics.

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Addition of Amphotericin B to Optisol-GS Needs Further Study

MONDAY, Feb. 29, 2016 (HealthDay News) -- Further investigation of the addition of amphotericin B to Optisol-GS, the most commonly used corneal storage medium in the United States, is warranted, according to research published online Feb. 25 in JAMA Ophthalmology.

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Drug-Induced Liver Injury From Chinese, Western Meds Varies

MONDAY, Feb. 29, 2016 (HealthDay News) -- Chinese herbal medicine (CHM) and Western medicine (WM) have different effects as causes of drug-induced liver injury (DILI), according to a study published online Feb. 20 in the Journal of Gastroenterology and Hepatology.

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Some Women Lack Interest in Sex With New Contraceptive

THURSDAY, Feb. 25, 2016 (HealthDay News) -- Almost one-quarter of women report lacking interest in sex at six months after initiating a new contraceptive method, compared to over 40 percent of women using no contraceptive method, according to a study published in the March issue of Obstetrics & Gynecology.

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Topical Dorzolamide-Timolol Beneficial in Neovascular AMD

FRIDAY, Feb. 26, 2016 (HealthDay News) -- Topical dorzolamide hydrochloride-timolol appears to reduce central subfield thickness and subretinal fluid in eyes of patients with neovascular age-related macular degeneration (AMD) and incomplete response to anti-vascular endothelial growth factor (VEGF) therapy, according to a study published online Feb. 25 in JAMA Ophthalmology.

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Dispositional Mindfulness Tied to Improved Glucose Regulation

FRIDAY, Feb. 26, 2016 (HealthDay News) -- Dispositional mindfulness seems to be associated with improved glucose regulation, according to a study published in the March issue of the American Journal of Health Behavior.

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CDC: Flu Season Continues to Be Mild; Vaccine Is Effective

THURSDAY, Feb. 25, 2016 (HealthDay News) -- This flu season continues to be mild, while the flu vaccine is working better than the one used last season, with an overall efficacy of 59 percent, according to the U.S. Centers for Disease Control and Prevention.

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Point-of-Sale Education Needed for Cannabis Tourists

THURSDAY, Feb. 25, 2016 (HealthDay News) -- The rates of emergency department visits possibly related to marijuana use have increased disproportionately for out-of-state visitors compared with Colorado residents, according to a research letter published in the Feb. 25 issue of the New England Journal of Medicine.

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Zolpidem Use Linked to Motor Vehicle Collisions in Elderly

THURSDAY, Feb. 25, 2016 (HealthDay News) -- Zolpidem users, especially women and individuals aged ≥80 years, have higher rates of motor vehicle collisions (MVCs), according to a study published online in Sleep Medicine.

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Weekly Paclitaxel Doesn't Up Survival in Ovarian Cancer

THURSDAY, Feb. 25, 2016 (HealthDay News) -- Dose-dense weekly paclitaxel does not improve progression-free survival in ovarian cancer, according to a study published in the Feb. 25 issue of the New England Journal of Medicine.

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Suggestions for Optimizing Practice Feedback Effectiveness

THURSDAY, Feb. 25, 2016 (HealthDay News) -- In an article published online Feb. 23 in the Annals of Internal Medicine, 15 suggestions are presented to optimize the effectiveness of practice feedback.

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No Benefit From Aspirin Prior to Coronary Artery Surgery

WEDNESDAY, Feb. 24, 2016 (HealthDay News) -- Preoperative aspirin does not lower risk of death or thrombotic complications among patients undergoing coronary artery surgery, according to research published in the Feb. 25 issue of the New England Journal of Medicine.

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Curcumin May Help Prevent Liver Damage From Acetaminophen

WEDNESDAY, Feb. 24, 2016 (HealthDay News) -- Curcumin exerts a hepatoprotective effect against acetaminophen-induced damage in mice, according to an experimental study published in the February issue of the Journal of Pharmacy and Pharmacology.

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Benzodiazepine Prescriptions Rose From 1996 to 2013

WEDNESDAY, Feb. 24, 2016 (HealthDay News) -- Benzodiazepine prescriptions and overdose deaths increased considerably from 1996 to 2013, according to a study published online Feb. 18 in the American Journal of Public Health.

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Authors Urge Caution Before Adopting New Systolic BP Goals

WEDNESDAY, Feb. 24, 2016 (HealthDay News) -- A small reduction as the primary composite outcome may not justify the increased adverse events and costs associated with an intervention targeting systolic blood pressure (BP) less than 120 mm Hg, according to an Ideas and Opinions piece published online Feb. 23 in the Annals of Internal Medicine.

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Macrolide Antibiotics Not Linked to Ventricular Arrhythmia

WEDNESDAY, Feb. 24, 2016 (HealthDay News) -- For older adults, macrolide antibiotics are not associated with a higher risk of ventricular arrhythmia within 30 days compared with nonmacrolide antibiotics, according to a study published online Feb. 22 in CMAJ, the journal of the Canadian Medical Association.

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Prednisolone Deemed Safe, Effective First-Line Acute Gout Rx

TUESDAY, Feb. 23, 2016 (HealthDay News) -- For patients with acute gout, prednisolone has similar analgesic effectiveness to indomethacin, according to a study published online Feb. 23 in the Annals of Internal Medicine.

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ACOG: Vaginal Estrogen Can Be Used for Breast Cancer Survivors

TUESDAY, Feb. 23, 2016 (HealthDay News) -- Use of vaginal estrogen should be carefully considered by women with a history of estrogen-dependent breast cancer, according to a Committee Opinion published in the March issue of Obstetrics & Gynecology.

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4vHPV Type Prevalence Down After Vaccine Introduction

TUESDAY, Feb. 23, 2016 (HealthDay News) -- Introduction of the human papillomavirus (HPV) vaccine has correlated with a reduction in quadrivalent HPV (4vHPV) type prevalence among females aged 14 to 19 and 20 to 24 years, according to a study published online Feb. 22 in Pediatrics.

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Early Administration of β-Blockers Ups Survival in ACS

MONDAY, Feb. 22, 2016 (HealthDay News) -- For patients with acute coronary syndromes (ACS), early administration of β-blockers is associated with increased short-term survival and improved left ventricular function, according to a study published in the March 1 issue of The American Journal of Cardiology.

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Combination Treatment for Acne May Be Best in Most Cases

MONDAY, Feb. 22, 2016 (HealthDay News) -- An evidence-based guideline for the management of acne vulgaris has been published online Feb. 17 in the Journal of the American Academy of Dermatology.

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Birth Defects Not Up Significantly With Anti-TNFs in Pregnancy

MONDAY, Feb. 22, 2016 (HealthDay News) -- Birth defects are not significantly more prevalent among women receiving anti-tumor necrosis factor (TNF) agents during pregnancy, according to a study published in the February issue of Clinical Gastroenterology and Hepatology.

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G-Pen May Aid Hypoglycemia With Type 1 Diabetes

MONDAY, Feb. 22, 2016 (HealthDay News) -- Mini-dose glucagon administered using a stable, ready-to-use G-Pen Mini glucagon may be an effective option for mild to moderate hypoglycemia in adults with type 1 diabetes, according to a study published online Feb. 9 in Diabetes Care.

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Topical Rx Restores Testosterone Levels to Normal in Men

MONDAY, Feb. 22, 2016 (HealthDay News) -- Application of once-daily topical testosterone effectively restores normal testosterone levels in men, according to a study published in the March issue of The Journal of Urology.

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Only Half of Kidney Stone Patients Compliant With Tx

FRIDAY, Feb. 19, 2016 (HealthDay News) -- Just over half of kidney stone patients are adherent to preventive pharmacological therapy, and adherent patients have lower levels of health care utilization, according to a study published in the March issue of The Journal of Urology.

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FDA Approves Briviact for Partial Onset Seizures

FRIDAY, Feb. 19, 2016 (HealthDay News) -- Briviact (brivaracetam) has been approved by the U.S. Food and Drug Administration to treat partial onset seizures in people aged 16 and older with epilepsy.

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Feedback From High-Profile Messenger Can Cut Antibiotic Rx

FRIDAY, Feb. 19, 2016 (HealthDay News) -- Feedback from a high-profile messenger can reduce antibiotic prescribing on a national scale, according to a study published online Feb. 18 in The Lancet.

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High-Dose Sugammadex Speeds Reversal of Neuromuscular Block

FRIDAY, Feb. 19, 2016 (HealthDay News) -- Sugammadex at a dose of 4 mg/kg−1 of ideal body weight allows for shorter reversal of deep neuromuscular blockade in morbidly obese patients, according to a study published in the March issue of Anaesthesia.

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Calcium Channel Blockers Lower Fasting Glucose in Diabetes

FRIDAY, Feb. 19, 2016 (HealthDay News) -- For adults with diabetes, calcium channel blocker (CCB) use is associated with lower fasting serum glucose levels, according to a study published online Jan. 15 in Diabetes Research and Clinical Practice.

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Three Classes of Antibiotic-Associated Encephalopathy ID'd

FRIDAY, Feb. 19, 2016 (HealthDay News) -- Antibiotic-associated encephalopathy (AAE) can be classified into three unique clinical phenotypes, according to research published online Feb. 17 in Neurology.

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Botulinum Toxin Ups Physical, Mental Health in Hyperhidrosis

FRIDAY, Feb. 19, 2016 (HealthDay News) -- For patients with hyperhidrosis, botulinum toxin treatment is associated with significant improvements in mental and physical health, according to a study published online Feb. 15 in the Journal of Dermatology.

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Testosterone Therapy Offers Modest Benefits for Older Men

THURSDAY, Feb. 18, 2016 (HealthDay News) -- Testosterone treatment may offer moderate benefit in improving sexual function in older men, but further research is needed to establish possible risks, according to research published in the Feb. 18 issue of the New England Journal of Medicine.

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Intensive Diabetes Therapy Cuts CVD Incidence by 30 Percent

THURSDAY, Feb. 18, 2016 (HealthDay News) -- Participants who were taught intensive therapy for type 1 diabetes during the Diabetes Control and Complications Trial (DCCT) experienced clinically beneficial effects on cardiovascular outcomes at 30 years of follow-up, according to research published online Feb. 9 in Diabetes Care.

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Letrozole Tied to Ovarian Function Recovery in Chemo

THURSDAY, Feb. 18, 2016 (HealthDay News) -- Some women aged 40 to 49 years with estrogen receptor-positive breast cancer who undergo chemotherapy-induced amenorrhea regain ovarian function with letrozole, according to a study published online Feb. 16 in the Journal of Clinical Oncology.

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Cannabis Use Not Linked to Risk of Mood, Anxiety Disorders

WEDNESDAY, Feb. 17, 2016 (HealthDay News) -- Cannabis use is not associated with increased risk of mood or anxiety disorders, but is associated with increased risk of several substance use disorders within the general population, according to research published online Feb. 17 in JAMA Psychiatry.

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Nonmedical Stimulant Use Up Among Adults, Not Teens

TUESDAY, Feb. 16, 2016 (HealthDay News) -- Nonmedical stimulant use has increased among adults in recent years, according to a study published online Feb. 16 in the Journal of Clinical Psychiatry.

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ESAs Don't Improve Quality of Life in Anemia of CKD

TUESDAY, Feb. 16, 2016 (HealthDay News) -- Erythropoietin-stimulating agents (ESAs) do not improve health-related quality of life (HRQOL) in patients with anemia of chronic kidney disease (CKD), according to a review published online Feb. 16 in the Annals of Internal Medicine.

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Vitamin E Neuroprotective Against Cisplatin Ototoxicity

TUESDAY, Feb. 16, 2016 (HealthDay News) -- Vitamin E supplementation can reduce cisplatin (CDDP)-induced ototoxicity, according to a study published online Feb. 5 in Head & Neck.

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Continuous Oral Contraceptives Better After Endometriosis Sx

TUESDAY, Feb. 16, 2016 (HealthDay News) -- For patients after surgery for endometriosis, a continuous oral contraceptive schedule seems better than a cyclic schedule, according to a review published in the February issue of the American Journal of Obstetrics & Gynecology.

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Proton Pump Inhibitors Linked to Increased Dementia Risk

MONDAY, Feb. 15, 2016 (HealthDay News) -- Proton pump inhibitors (PPIs) may be tied to the development of dementia in the elderly, according to a study published online Feb. 15 in JAMA Neurology.

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ECDC Publishes Report on Bacterial Antimicrobial Resistance

MONDAY, Feb. 15, 2016 (HealthDay News) -- Bacteria in humans, food, and animals continue to show resistance to commonly used antimicrobials, according to a report published online Feb. 11 by the European Food Safety Authority (EFSA) and the European Centre for Disease Prevention and Control (ECDC).

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Opioids Tied to Higher Risk of Infections in Rheumatoid Arthritis

MONDAY, Feb. 15, 2016 (HealthDay News) -- The use of opioid analgesics may increase the risk of serious infection in patients with rheumatoid arthritis (RA), according to research published in the February issue of Arthritis & Rheumatology.

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Net Returns Projected to Top Investment in Vaccines

MONDAY, Feb. 15, 2016 (HealthDay News) -- Projected immunizations are estimated to yield returns that are greater than costs in low- and middle-income countries during 2011 to 2020, according to a study published in the February issue of Health Affairs.

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Texting Intervention Promotes Weight Loss in Prediabetes

MONDAY, Feb. 15, 2016 (HealthDay News) -- For patients with prediabetes offered Diabetes Prevention Program (DPP) classes, text message support can enhance weight loss, according to a study published online Feb. 9 in Diabetes Care.

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Fat, Carbohydrate Quality Impact Postprandial Blood Glucose

FRIDAY, Feb. 12, 2016 (HealthDay News) -- For patients with type 1 diabetes, fat quality influences postprandial blood glucose (PPG) response in the context of meals with high-glycemic index (HGI), according to a study published online Feb. 9 in Diabetes Care.

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Vignette Highlights Management of Recurrent UTI in Older Men

FRIDAY, Feb. 12, 2016 (HealthDay News) -- In a case vignette published in the Feb. 11 issue of the New England Journal of Medicine, recommendations are presented for management of recurrent acute febrile urinary tract infections in older men.

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Dexamethasone No Help in HIV-Linked Cryptococcal Meningitis

FRIDAY, Feb. 12, 2016 (HealthDay News) -- For patients with HIV-associated cryptococcal meningitis, dexamethasone does not reduce mortality compared with placebo, according to a study published in the Feb. 11 issue of the New England Journal of Medicine.

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CDC: Number of Uninsured Persons in U.S. Down Since 2013

FRIDAY, Feb. 12, 2016 (HealthDay News) -- The percentage of uninsured persons is decreasing in the United States, according to a report published by the National Center for Health Statistics (NCHS).

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Use of Digoxin Down Among Patients With Heart Failure

FRIDAY, Feb. 12, 2016 (HealthDay News) -- Only one-in-five patients with heart failure with reduced ejection fraction (HFrEF) receive digoxin at discharge, according to a study published online Feb. 10 in JACC: Heart Failure.

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Functional Imaging Beneficial for Analgesic Drug Development

FRIDAY, Feb. 12, 2016 (HealthDay News) -- Functional magnetic resonance imaging with central sensitization can be used in early human drug development, according to a study published in the January issue of Anesthesiology.

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Sedatives Appear to Be Safe in Alcohol Withdrawal Syndrome

FRIDAY, Feb. 12, 2016 (HealthDay News) -- For patients with alcohol withdrawal syndrome, treatment with high-dose intravenous sedatives is not associated with excess morbidity or mortality, according to a study published in the February issue of the American Journal of Respiratory and Critical Care Medicine.

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Physicians Concerned By Increasing Cost of Generics

THURSDAY, Feb. 11, 2016 (HealthDay News) -- Pennsylvania physicians have called for state- and national-level medical associations to take an active role in addressing the issue of increasing generic drug prices, according to an article published by the Pennsylvania Medical Society.

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Caplacizumab Shows Potential for Treating Acquired TTP

THURSDAY, Feb. 11, 2016 (HealthDay News) -- Caplacizumab, an anti-von Willebrand factor humanized single-variable-domain immunoglobulin (Nanobody), shows potential in the treatment of acquired thrombotic thrombocytopenic purpura (TTP), according to research published in the Feb. 11 issue of the New England Journal of Medicine.

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Euthanasia/Assisted Suicide for Psychiatric Disorders Examined

THURSDAY, Feb. 11, 2016 (HealthDay News) -- Patients receiving euthanasia or assisted suicide (EAS) for psychiatric disorders are mainly women and most have chronic, severe conditions, according to a study published online Feb. 10 in JAMA Psychiatry.

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Durable Response With Insulin Pump Therapy in T2DM

THURSDAY, Feb. 11, 2016 (HealthDay News) -- Insulin pump therapy is more effective than multiple daily injections (MDI) for glycemic control in patients with type 2 diabetes, according to a study published online Feb. 8 in Diabetes, Obesity and Metabolism.

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No Need to Avoid Statins in Hep C Compensated Cirrhosis

WEDNESDAY, Feb. 10, 2016 (HealthDay News) -- Statin use is associated with decreased risk of cirrhosis decompensation and death in patients with hepatitis C virus (HCV)-related compensated cirrhosis, according to research published in the February issue of Gastroenterology.

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Recurrent Erythema Seen With H. cinaedi Bacteremia

WEDNESDAY, Feb. 10, 2016 (HealthDay News) -- Recurrent superficial cellulitis-like erythema is associated with Helicobacter cinaedi (H. cinaedi) bacteremia, according to a case report published online Jan. 30 in The Journal of Dermatology.

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Cola Intake Increases Exposure of Erlotinib

WEDNESDAY, Feb. 10, 2016 (HealthDay News) -- Cola intake leads to a clinically relevant and statistically significant increase in the bioavailability of erlotinib during esomeprazole treatment, according to a study published online Feb. 8 in the Journal of Clinical Oncology.

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Behavioral Interventions Can Cut Inappropriate Antibiotic Use

TUESDAY, Feb. 9, 2016 (HealthDay News) -- Use of certain behavioral interventions can reduce the rates of inappropriate antibiotic prescribing during ambulatory visits for acute respiratory tract infections, according to a study published in the Feb. 9 issue of the Journal of the American Medical Association.

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Postpartum Hemorrhage Up With Specific Antidepressants

TUESDAY, Feb. 9, 2016 (HealthDay News) -- Exposure to serotonin-norepinephrine reuptake inhibitors in late pregnancy is associated with increased risk of postpartum hemorrhage, according to a study published in the March issue of Obstetrics & Gynecology.

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CBT May Work As Well As Meds in Major Depressive Disorder

TUESDAY, Feb. 9, 2016 (HealthDay News) -- For adults with major depressive disorder, cognitive behavioral therapy (CBT) and antidepressants have similar efficacy, according to a clinical guideline published online Feb. 9 in the Annals of Internal Medicine.

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Botox May Reduce Chronic Neuropathic Pain

TUESDAY, Feb. 9, 2016 (HealthDay News) -- Subcutaneous botulinum toxin type A (BTX-A) injections appear to safely and effectively reduce chronic neuropathic pain in patients with spinal cord injury, according to a study published online Jan. 27 in the Annals of Neurology.

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AMA Highlights Issues Relating to Medical Liability Reform

MONDAY, Feb. 8, 2016 (HealthDay News) -- Medical liability reforms are likely to be advanced and challenged in 2016, according to a report published by the American Medical Association (AMA).

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Folic Acid Consumption in First Trimester Linked to GDM Risk

MONDAY, Feb. 8, 2016 (HealthDay News) -- Folic acid (FA) consumption in the first trimester is associated with increased risk of gestational diabetes mellitus (GDM), according to research published online Jan. 28 in Diabetes Care.

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Influenza Infection Tied to Increased Risk of A-Fib

MONDAY, Feb. 8, 2016 (HealthDay News) -- Influenza infection is associated with increased odds of atrial fibrillation (AF), which can be reduced through vaccination, according to a study published online Feb. 1 in Heart Rhythm.

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Central Retinal Vein Occlusion ID'd After Phendimetrazine Use

MONDAY, Feb. 8, 2016 (HealthDay News) -- A case of central retinal vein occlusion (CRVO) two days after phendimetrazine use has been documented and published online Feb. 4 in JAMA Ophthalmology.

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Doctors Offer Suggestions for Electronic Health Records

FRIDAY, Feb. 5, 2016 (HealthDay News) -- Physicians recently met in Seattle to discuss the difficulties and benefits associated with electronic health records (EHRs) in a third town hall meeting on the subject, according to a report published by the American Medical Association.

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Planned Parenthood Exclusion Cuts Contraceptive Provision

FRIDAY, Feb. 5, 2016 (HealthDay News) -- Exclusion of the Planned Parenthood affiliates in Texas is associated with a reduction in the provision of contraception, according to a study published online Feb. 3 in the New England Journal of Medicine.

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High-Dose Statins Benefit Some Cases of Macular Degeneration

FRIDAY, Feb. 5, 2016 (HealthDay News) -- High doses of statin medications may benefit age-related macular degeneration (AMD), according to research to be published in EBioMedicine.

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Routine Amoxicillin Use of No Benefit in Acute Malnutrition

THURSDAY, Feb. 4, 2016 (HealthDay News) -- Routine use of amoxicillin does not improve nutritional recovery from uncomplicated severe acute malnutrition in children, according to research published in the Feb. 4 issue of the New England Journal of Medicine.

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Minimal Benzodiazepine Exposure May Up Dementia Risk

THURSDAY, Feb. 4, 2016 (HealthDay News) -- Patients with minimal exposure to benzodiazepine have a slightly increased risk of dementia, according to a study published online Feb. 2 in The BMJ.

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Safety Issues Raised in Key Trial Supporting Rivaroxaban Use

THURSDAY, Feb. 4, 2016 (HealthDay News) -- Use of a faulty device in a regulatory drug trial has raised questions relating to rivaroxaban use, according to a feature article published online Feb. 3 in The BMJ.

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High Rate of Clopidogrel Non-Adherence After DES Placement

THURSDAY, Feb. 4, 2016 (HealthDay News) -- For patients undergoing drug-eluting stent placement, there is a high rate of clopidogrel nonadherence, according to a study published in the Feb. 15 issue of The American Journal of Cardiology.

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Self-Reported Penicillin Allergy May Actually Be Chronic Urticaria

WEDNESDAY, Feb. 3, 2016 (HealthDay News) -- Patients who self-report penicillin allergy might actually have chronic urticaria, according to a study published online Jan. 9 in the Annals of Allergy, Asthma & Immunology.

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Antenatal Metformin Cuts Maternal Weight Gain in Obese

WEDNESDAY, Feb. 3, 2016 (HealthDay News) -- For obese women, metformin administration during pregnancy is associated with reduced maternal weight gain, without reducing median neonatal birth weight, according to a study published in the Feb. 4 issue the New England Journal of Medicine.

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ACIP Approves 2016 Adult Immunization Schedule

WEDNESDAY, Feb. 3, 2016 (HealthDay News) -- The Advisory Committee on Immunization Practices (ACIP) has approved the recommended adult immunization schedule for 2016. The recommendations are published as a clinical guideline in the Feb. 2 issue of the Annals of Internal Medicine.

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Neutral Long-Term Effect for Intensive Glycemic Control

WEDNESDAY, Feb. 3, 2016 (HealthDay News) -- During long-term follow-up, the impact of a four-year period of intensive glycemic control has a neutral effect on death and nonfatal cardiovascular events, according to a study published online Jan. 28 in Diabetes Care.

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Less Than Half of U.S. Infants Fully Vaccinated for Influenza

WEDNESDAY, Feb. 3, 2016 (HealthDay News) -- Although full influenza vaccination coverage is increasing among children aged 6 to 23 months, less than half of children in the United States were fully vaccinated in the 2011 to 2012 influenza season, according to a study published online Feb. 2 in Pediatrics.

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Intubation Duration for COPD Unchanged by Acetazolamide

WEDNESDAY, Feb. 3, 2016 (HealthDay News) -- Acetazolamide does not differ from placebo in effect on the duration of invasive mechanical ventilation in patients with chronic obstructive pulmonary disease (COPD), according to research published in the Feb. 2 issue of the Journal of the American Medical Association.

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Subcutaneous Dupilumab Reduces Nasal Polyp Burden

TUESDAY, Feb. 2, 2016 (HealthDay News) -- For adults with symptomatic chronic sinusitis and nasal polyposis refractory to intranasal corticosteroids, subcutaneous dupilumab added to mometasone furoate nasal spray is associated with reduced nasal polyp score, according to a study published in the Feb. 2 issue of the Journal of the American Medical Association.

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Protein Preload Boosts Vildagliptin's Effects in Diabetes

TUESDAY, Feb. 2, 2016 (HealthDay News) -- A protein preload enhances the glucose-lowering efficacy of vildagliptin in type 2 diabetes, according to a study published online Jan. 19 in Diabetes Care.

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Tips Presented for Encouraging Treatment Adherence

TUESDAY, Feb. 2, 2016 (HealthDay News) -- Tips for increasing patient adherence to treatment plans include patient engagement and addressing barriers to adherence, according to an article published in Medical Economics.

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2016 Childhood Immunization Schedule Released

TUESDAY, Feb. 2, 2016 (HealthDay News) -- The 2016 recommended immunization schedule for children and adolescents has been approved, according to a policy statement published online Feb. 1 in Pediatrics.

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Novel Vaccine Platform Shows Promise for HIV-1

TUESDAY, Feb. 2, 2016 (HealthDay News) -- Two HIV-1 vaccines, which include adenovirus and an HIV-1 envelope A insert, elicit significant immune responses in healthy adults without HIV infection, according to a study published online Feb. 2 in the Annals of Internal Medicine.

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Lower Risk of Contrast-Induced Nephropathy With Iodixanol

TUESDAY, Feb. 2, 2016 (HealthDay News) -- Iodixanol is associated with lower risk for contrast-induced nephropathy (CIN) versus low-osmolar contrast media (LOCM); and among those receiving LOCM, the greatest risk reduction is seen for N-acetylcysteine and statins plus N-acetylcysteine, according to two reviews published online Feb. 2 in the Annals of Internal Medicine.

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Researchers Say JNC8 Recs May Put Some Patients at Risk

TUESDAY, Feb. 2, 2016 (HealthDay News) -- For people 60 and older, the Eighth Joint National Committee (JNC8) in 2014 recommended raising the blood pressure level at which doctors prescribe treatment from 140 to 150 systolic blood pressure. But individuals with systolic blood pressure of 140 to 149 have a 70 percent increased risk of stroke compared to people with lower blood pressure, according to research published online Feb. 1 in Hypertension.

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Opioids Don't Ease Disability in Neuropathic Pain

MONDAY, Feb. 1, 2016 (HealthDay News) -- Taking prescription opioids doesn't improve movement or reduce disability for patients with neuropathic pain, according to a study published recently in Pain Medicine.

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Mobile Texts May Up Adherence to Meds for Chronic Illness

MONDAY, Feb. 1, 2016 (HealthDay News) -- Mobile telephone text messaging may be a promising new way to improve adherence to medications for chronic diseases, according to research published online Feb. 1 in JAMA Internal Medicine.

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Palliative Care Lacking for Chronic Lung Disease Patients

MONDAY, Feb. 1, 2016 (HealthDay News) -- Among patients who die in the intensive care unit (ICU), patients with chronic lung diseases receive fewer elements of palliative care than cancer patients, according to a study published online Jan. 19 in the Annals of the American Thoracic Society.

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Many Physicians Show Tendency to Undertreat With Statins

MONDAY, Feb. 1, 2016 (HealthDay News) -- Some clinical departments tend to undertreat when prescribing statins, according to a study published in the February issue of the Journal of Clinical Pharmacy and Therapeutics.

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No Benefit From Aliskiren-Tied Drops in Albuminuria

MONDAY, Feb. 1, 2016 (HealthDay News) -- Reduction in albuminuria with the renin inhibitor aliskiren may be too small to confer clinical benefit in patients with type 2 diabetes, according to a study published online Jan. 13 in Diabetes, Obesity and Metabolism.

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ASTRO: No Survival Benefit for Adding EBT to Brachytherapy

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Addition of external beam therapy doesn't improve five-year progression-free survival in prostate cancer

ASTRO: Fewer Side Effects With IMRT in Cervical, Endometrial CA

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Patients in conventional radiotherapy arm had more high-level adverse events than those in IMRT arm

Many Doctors Reluctant to Reveal Mental Health Issues

Many Doctors Reluctant to Reveal Mental Health Issues

Perceived stigma, fear of career repercussions hinder treatment, study suggests

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