FDA Approves Yondelis for Soft-Tissue Sarcoma

Share this content:
FDA Approves Yondelis for Soft-Tissue Sarcoma
FDA Approves Yondelis for Soft-Tissue Sarcoma

FRIDAY, Oct. 23, 2015 (HealthDay News) -- The chemotherapy drug Yondelis (trabectedin) has been approved by the U.S. Food and Drug Administration to treat certain advanced or unresectable soft-tissue sarcomas (STS).

Yondelis is approved for patients with two forms of STS -- liposarcoma or leiomyosarcoma -- who have had previous treatment with chemotherapy containing anthracycline, the FDA said.

Yondelis was evaluated in clinical studies involving 518 patients. Patients who took Yondelis had average progression-free survival of 4.2 months, compared to an average of 1.5 months among those who took dacarbazine, the agency said.

The most common side effects of Yondelis include nausea, fatigue, vomiting, diarrhea, constipation, loss of appetite, dyspnea, headache, and peripheral edema. The drug's label warns of the possibility of more serious side effects, including neutropenic sepsis, rhabdomyolysis, hepatotoxicity, leakage around the vein or catheter, tissue necrosis, and cardiomyopathy. It also warns women of childbearing age of potential harm to a developing fetus, and against breastfeeding while on the drug.

Yondelis is marketed by Janssen Products, based in Raritan, N.J.

More Information

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »