FDA Approves Bridion to Reverse Neuromuscular Blockade

Share this content:
FDA Approves Bridion to Reverse Neuromuscular Blockade
FDA Approves Bridion to Reverse Neuromuscular Blockade

WEDNESDAY, Dec. 16, 2015 (HealthDay News) -- Bridion (sugammadex) has been approved by the U.S. Food and Drug Administration to reverse the effects of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide.

The neuromuscular blocking drugs are used to paralyze the vocal cords during tracheal intubation, to prevent a patient receiving general anesthesia from moving during surgery, or to prevent a patient from breathing automatically while on a ventilator, the FDA said.

In clinical studies involving 456 patients, Bridion was evaluated in reversing the effects of these drugs. Most of the patients who received Bridion recovered within 5 minutes of its use, the FDA said. However, the agency warned of the possibility of life-threatening allergic-like reaction to Bridion, an outcome that affected one of 299 clinical trial participants given the drug. Another possible severe reaction is marked bradycardia, which could lead to cardiac arrest, the FDA said. More common and less severe side effects of Bridion could include vomiting, hypotension, pain, headache, and nausea. The drug also could reduce the effectiveness of certain hormonal contraceptives taken by women.

"Bridion provides a new treatment option that may help patients recover sooner from medications used for intubation or ventilation during surgery," Sharon Hertz, M.D., director of the Division of Anesthesia, Analgesia and Addiction Products in the FDA's Center for Drug Evaluation and Research, said in a statement. "This drug enables medical personnel to reverse the effects of neuromuscular blocking drugs and restore spontaneous breathing after surgery."

Bridion is marketed by a subsidiary of Merck and Co., based in Whitehouse Station, N.J.

More Information

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

FDA OKs Doptelet for Liver Dz Patients Undergoing Procedures

FDA OKs Doptelet for Liver Dz Patients Undergoing ...

Doptelet reduces the need for platelet transfusion or any rescue therapy on day of procedure

Slower Decline in Lung Function With Anthocyanin Intake

Slower Decline in Lung Function With Anthocyanin Intake

Slower annual rates of decline in FEV1 and FVC for those in highest quartile of anthocyanin intake

Bioengineering Feasible for Airway Reconstruction

Bioengineering Feasible for Airway Reconstruction

Bioengineered tracheal and bronchial reconstruction reported using stented aortic matrices

is free, fast, and customized just for you!

Already a member?

Sign In Now »