Favorable Physiological Effect for Ularitide in Acute Heart Failure

This article originally appeared here.
Share this content:
Favorable Physiological Effect for Ularitide in Acute Heart Failure
Favorable Physiological Effect for Ularitide in Acute Heart Failure

THURSDAY, April 13, 2017 (HealthDay News) -- Ularitide has a favorable physiological effect in patients with acute heart failure, according to a study published online April 12 in the New England Journal of Medicine.

Milton Packer, M.D., from the Baylor University Medical Center in Dallas, and colleagues conducted a double-blind trial involving 2,157 patients with acute heart failure who were randomized to receive a continuous intravenous infusion of ularitide (15 ng/kg body weight/minute) or matching placebo for 48 hours in addition to standard therapy.

The researchers found that 236 patients in the ularitide group and 225 in the placebo group died of cardiovascular causes during a median follow-up of 15 months (21.7 versus 21.0 percent; hazard ratio, 1.03; 95 percent confidence interval, 0.85 to 1.25; P = 0.75). There was no significant difference between the groups with respect to the hierarchical composite outcome that evaluated the initial 48-hour clinical course. Compared with the placebo group, the ularitide group had greater reductions in systolic blood pressure and in levels of N-terminal pro-brain natriuretic peptide. In the 55 percent of patients with paired data, there was no difference between the groups in changes in cardiac troponin T levels during the infusion.

"In patients with acute heart failure, ularitide exerted favorable physiological effects (without affecting cardiac troponin levels), but short-term treatment did not affect a clinical composite end point or reduce long-term cardiovascular mortality," the authors write.

The study was funded by Cardiorentis, which is developing ularitide.

Abstract
Full Text
Editorial

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

High Success Rates for Mitral Valve Repair With Robotic Surgery

High Success Rates for Mitral Valve Repair With ...

Minimally invasive surgery linked to fewer discharges to facility, one day less in hospital vs conservative sx

Tattoo-Linked Complications ID'd in Immunosuppressed Female

Tattoo-Linked Complications ID'd in Immunosuppressed Female

Inflammatory myopathy identified in woman with cystic fibrosis on long-term immunosuppressants

Rates of Cardiac Stress Testing Down but Still Higher in CKD

Rates of Cardiac Stress Testing Down but Still ...

Decline in rates of cardiac stress testing in Medicare beneficiaries aged ≥66 years from 2008 to 2012

is free, fast, and customized just for you!




Already a member?

Sign In Now »