Fatty Acid Binding Protein 4 Tied to Preeclampsia Risk in T1DM

Share this content:
Fatty Acid Binding Protein 4 Tied to Preeclampsia Risk in T1DM
Fatty Acid Binding Protein 4 Tied to Preeclampsia Risk in T1DM

WEDNESDAY, Sept. 21, 2016 (HealthDay News) -- For women with type 1 diabetes, elevated fatty acid binding protein 4 (FABP4) in early pregnancy and in the second trimester is associated with subsequent preeclampsia, according to a study published online Sept. 14 in Diabetes Care.

Amy C. Wotherspoon, from Queen's University in Belfast, U.K., and colleagues measured serum FABP4 in 710 women from the Diabetes and Pre-eclampsia Intervention Trial in early pregnancy (median 14 weeks of gestation) and in the second trimester (median 26 weeks of gestation).

The researchers found that in women in whom preeclampsia later developed, FABP4 was significantly elevated in early pregnancy and the second trimester (both P < 0.001). There was an independent association for elevated second-trimester FABP4 level with preeclampsia (odds ratio, 2.87; P = 0.03). At both time points, the addition of FABP4 to established risk factors significantly improved net reclassification improvement, and integrated discrimination improvement in the second trimester.

"Increased second-trimester FABP4 independently predicted preeclampsia and significantly improved reclassification and discrimination," the authors write. "FABP4 shows potential as a novel biomarker for preeclampsia prediction in women with type 1 diabetes."

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

RSNA: Sleep Deprivation Appears to Affect Heart Function

RSNA: Sleep Deprivation Appears to Affect Heart Function

Small study finds lack of sleep affects blood pressure, heart rate in healthy volunteers

Three Low-Carb Meals a Day Can Lower Insulin Resistance

Three Low-Carb Meals a Day Can Lower Insulin ...

However, pre-meal exercising not helpful in reducing evening blood glucose levels

Augmented Reality, Gaming May Help Relieve Phantom Limb Pain

Augmented Reality, Gaming May Help Relieve Phantom Limb ...

Study finds exercising virtual limb can cut pain by as much as half

is free, fast, and customized just for you!

Already a member?

Sign In Now »