Failure of Dual Antimicrobial Therapy for Gonorrhea Reported

Share this content:
Failure of Dual Antimicrobial Therapy for Gonorrhea Reported
Failure of Dual Antimicrobial Therapy for Gonorrhea Reported

THURSDAY, June 23, 2016 (HealthDay News) -- In a case report published in the June 23 issue of the New England Journal of Medicine, dual antimicrobial therapy failure is described in the treatment of gonorrhea.

Helen Fifer, B.M.B.S., from Public Health England in London, and colleagues describe treatment failure with dual therapy in a heterosexual man with gonorrhea.

The authors note that Neisseria gonorrhoeae was detected in a urine specimen and pharyngeal swab, and in a culture of a urethral specimen. Based on testing with the disk-diffusion method, the N. gonorrhoeae strain was resistant to cefuroxime, ciprofloxacin, and tetracycline. The patient was treated with one intramuscular dose of ceftriaxone plus oral azithromycin; on day 15, a urine specimen was negative but a pharyngeal swab remained positive for N. gonorrhoeae. After repeat positive tests on days 79 and 98, the patient received a repeat dose of ceftriaxone and azithromycin; at the test of cure on day 112, the pharyngeal specimen was negative. In antimicrobial susceptibility testing, the strain was found to be resistant to ceftriaxone, azithromycin, cefixime, cefotaxime, penicillin, tetracycline, and ciprofloxacin, but was susceptible to spectinomycin.

"The patient was considered to have treatment failure because the post-treatment isolate was resistant to ceftriaxone and azithromycin, all specimens contained resistance determinants and identical sequence types, and reinfection was deemed to be unlikely," the authors write. "The treatment failure reflected difficulties in treating pharyngeal gonorrhea as compared with urogenital gonorrhea."

Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

ASA: Class-Specific Link Between Periodontal Disease and Stroke

ASA: Class-Specific Link Between Periodontal Disease and Stroke

Link strongest for thrombotic strokes, cardioembolic strokes

ASA: Not Enough Stroke Patients Being Treated With tPA

ASA: Not Enough Stroke Patients Being Treated With ...

Minorities, women, seniors on Medicare, rural residents less likely to be diagnosed in time for tPA

Cytomegalovirus May Up Risk of Diabetes, CVD in Some Women

Cytomegalovirus May Up Risk of Diabetes, CVD in ...

Conversely, for women with extreme obesity, CMV may offer protection against CVD, DM

is free, fast, and customized just for you!

Already a member?

Sign In Now »