Ezetimibe/Simvastatin Ups Clinical Outcomes in IMPROVE-IT

Share this content:
Ezetimibe/Simvastatin Ups Clinical Outcomes in IMPROVE-IT
Ezetimibe/Simvastatin Ups Clinical Outcomes in IMPROVE-IT

FRIDAY, Jan. 29, 2016 (HealthDay News) -- Lipid-lowering therapy with ezetimibe plus simvastatin is associated with improved clinical outcomes, with a reduction in total primary end point (PEP) events, according to a study published in the Feb. 2 issue of the Journal of the American College of Cardiology.

Noting that ezetimibe/simvastatin therapy in the Improved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) significantly reduced the first PEPs in patients after acute coronary syndromes, Sabina A. Murphy, M.P.H., from Brigham and Women's Hospital in Boston, and colleagues examined whether total PEP events would also be reduced. They examined all PEP events during a median of six years of follow-up in 18,144 patients randomized to ezetimibe/simvastatin or placebo/simvastatin.

The researcher found that there were 9,545 total PEP events (56 percent first events; 44 percent subsequent events). Compared with placebo/simvastatin, there was a reduction in total PEP events with ezetimibe/simvastatin (incidence-rate ratio [RR], 0.91; P = 0.007), and reductions in the three pre-specified secondary composite end points and the exploratory composite end point of cardiovascular (CV) death, myocardial infarction (MI), or stroke (RR, 0.88; P = 0.002). Decreases in total nonfatal MI and total nonfatal stroke drove the reduction in total events (RRs, 0.87 [P = 0.004] and 0.77 [P = 0.005], respectively).

"These data support continuation of intensive combination lipid-lowering therapy after an initial CV event," the authors write.

Several authors disclosed financial ties to biopharmaceutical companies, including Merck, which manufactures ezetimibe/simvastatin and funded the IMPROVE-IT study.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

ASTRO: No Survival Benefit for Adding EBT to Brachytherapy

ASTRO: No Survival Benefit for Adding EBT to ...

Addition of external beam therapy doesn't improve five-year progression-free survival in prostate cancer

ASTRO: Fewer Side Effects With IMRT in Cervical, Endometrial CA

ASTRO: Fewer Side Effects With IMRT in Cervical, ...

Patients in conventional radiotherapy arm had more high-level adverse events than those in IMRT arm

Many Doctors Reluctant to Reveal Mental Health Issues

Many Doctors Reluctant to Reveal Mental Health Issues

Perceived stigma, fear of career repercussions hinder treatment, study suggests

is free, fast, and customized just for you!

Already a member?

Sign In Now »