Extended-Spectrum Antibiotics No Benefit for Pediatric Appendicitis

Share this content:
Extended-Spectrum Antibiotics No Benefit for Pediatric Appendicitis
Extended-Spectrum Antibiotics No Benefit for Pediatric Appendicitis

FRIDAY, July 1, 2016 (HealthDay News) -- For children diagnosed with appendicitis undergoing appendectomy, extended-spectrum antibiotics seem to offer no advantage over narrower-spectrum agents, according to a study published online June 28 in Pediatrics.

Matthew P. Kronman, M.D., from the University of Washington in Seattle, and colleagues performed a retrospective cohort study involving children aged 3 to 18 years discharged between 2011 and 2013 with an appendicitis diagnosis and appendectomy performed. Data were included for 24,984 patients.

The researchers found that 70.7 percent of the patients had uncomplicated appendicitis and 29.3 percent had complicated appendicitis (postoperative length of stay of three or more days, central venous catheter placed, major or severe illness classification, or intensive care unit admission). Overall, 2.7 percent of patients experienced the primary outcome of 30-day readmission for wound infection or repeat abdominal surgery (1.1 and 6.4 percent, respectively, among uncomplicated and complicated cases [P < 0.001]). There was a significant correlation for extended-spectrum antibiotic exposure with the primary outcome in complicated (adjusted odds ratio, 1.43; 95 percent confidence interval, 1.06 to 1.93) but not uncomplicated (adjusted odds ratio, 1.32; 95 percent confidence interval, 0.88 to 1.98) appendicitis.

"Extended-spectrum antibiotics seem to offer no advantage over narrower-spectrum agents for children with surgically managed acute uncomplicated or complicated appendicitis," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions


Sign up for myCME e-newsletters


More in Home

Automated Central System Offers Time Savings for Pharmacists

Automated Central System Offers Time Savings for Pharmacists

Cart-fill process using new automated system is more efficient, frees up time for other roles

Therapeutic Horseback Riding Can Help Alleviate PTSD in Veterans

Therapeutic Horseback Riding Can Help Alleviate PTSD in ...

Study found statistically and clinically significant reduction in PTSD scores after six weeks of THR

Bariatric Surgery Linked to Discontinuing Diabetes Meds

Bariatric Surgery Linked to Discontinuing Diabetes Meds

Six-year antidiabetes treatment initiation rate also much lower after bariatric surgery

is free, fast, and customized just for you!

Already a member?

Sign In Now »