Exposure to Neuraminidase Inhibitors in Utero Not Harmful

Share this content:
Exposure to Neuraminidase Inhibitors in Utero Not Harmful
Exposure to Neuraminidase Inhibitors in Utero Not Harmful

WEDNESDAY, March 1, 2017 (HealthDay News) -- Exposure to neuraminidase inhibitors during pregnancy is not associated with adverse neonatal outcomes or congenital malformations, according to a study published online Feb. 28 in The BMJ.

Sophie Graner, M.D., Ph.D., from the Karolinska Institutet in Stockholm, and colleagues examined the possible effects of exposure to neuraminidase inhibitors during embryo-fetal life. Data were included for 5,824 exposed women and their infants and 692,232 non-exposed women.

The researchers found that in utero exposure to neuraminidase inhibitors was not associated with elevated risks of low birth weight (adjusted odds ratio [aOR], 0.77; 95 percent confidence interval [CI], 0.65 to 0.91), low Apgar score (aOR, 0.87; 95 percent CI, 0.67 to 1.14), preterm birth (adjusted hazard ratio, 0.97; 95 percent CI, 0.86 to 1.10), small-for-gestational-age birth (aOR, 0.72; 95 percent CI, 0.59 to 0.87), stillbirth (aOR, 0.81; 95 percent CI, 0.51 to 1.30), neonatal mortality (aOR, 1.13; 95 percent CI, 0.56 to 2.28), or neonatal morbidity (aOR, 0.92; 95 percent CI, 0.86 to 1.00). During the first trimester, there was no increased risk of congenital malformations overall in association with maternal exposure (aOR, 1.06; 95 percent CI, 0.77 to 1.48). In analysis restricted to oseltamivir alone, there were no significantly increased risks of any of the outcomes.

"The results support previously reported findings that the use of neuraminidase inhibitors is not associated with increased risks of adverse fetal or neonatal outcomes," the authors write.

One author disclosed financial ties to the Novo Nordisk Foundation.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions


Sign up for myCME e-newsletters


More in Home

FDA Warns of Possible Heart Risks Linked to Clarithromycin

FDA Warns of Possible Heart Risks Linked to ...

Agency advising doctors to consider prescribing other antibiotics to patients with coronary heart disease

Artificial Intelligence May Help Prevent Physician Burnout

Artificial Intelligence May Help Prevent Physician Burnout

Many potential uses for AI, including improving searches and documentation, selecting treatment

Benzodiazepine Use Declining in Older Adults

Benzodiazepine Use Declining in Older Adults

Findings based on assessment of incidence, prevalence of use in three countries from 2010-2016

is free, fast, and customized just for you!

Already a member?

Sign In Now »